Persistent influence of neonatal 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) treatment on glucocorticoid receptors and on the microsomal enzyme system

G. Csaba, O. Mag, A. Inczefi-Gonda, S. Szeberenyi

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28 Citations (Scopus)

Abstract

Neonatal treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) accounted for a considerable decrease in the number of thymic glycocorticoid receptors in both male and female rats, as assessed at 6 weeks of age. TCDD also gave rise to a marked and prolonged increase in microsomal enzyme activity in the female rats but had practically no such effect on the males. These experimental observations attract attention on to the lasting microsomal inducer effect of the herbicid contaminant dioxin which damages foreign receptors and substantiate the chemical imprinting potential of aromatic hydrocarbons.

Original languageEnglish
Pages (from-to)337-340
Number of pages4
JournalJournal of Developmental Physiology
Volume15
Issue number6
Publication statusPublished - 1991

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Glucocorticoid Receptors
Aromatic Hydrocarbons
Dioxins
Enzymes
Polychlorinated Dibenzodioxins

ASJC Scopus subject areas

  • Developmental Biology
  • Physiology

Cite this

Persistent influence of neonatal 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) treatment on glucocorticoid receptors and on the microsomal enzyme system. / Csaba, G.; Mag, O.; Inczefi-Gonda, A.; Szeberenyi, S.

In: Journal of Developmental Physiology, Vol. 15, No. 6, 1991, p. 337-340.

Research output: Contribution to journalArticle

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AU - Szeberenyi, S.

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