Persistent akinetic-rigid side effects of neuroleptics may indicate Wilson's disease.

Zsuzsanna Aschermann, F. Szalay, Erzsébet Schmidt, S. Komoly, Zsolt Illés

Research output: Contribution to journalArticle

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Abstract

Here we report two cases, where neuroleptic treatment provoked persistent akinetic-rigid symptoms resulting in the diagnosis of Wilson's disease. No liver function abnormalities suggested Wilson's disease in one of the cases. In both cases, the akinetic-rigid symptoms were originally attributed to side effects of neuroleptics, but symptoms persisted after discontinuation of treatment. In one of the cases, T2-weighted cranial MRI indicated bilateral hyperintense signals in the basal ganglia. Our cases suggest that in a subgroup of Wilson's disease, dopamine receptor antagonists may provoke akinetic-rigid neurological symptoms possibly due to the damage of dopaminergic neurons. Persistent akinetic-rigid side effects of neuroleptics in young patients thus require diagnostic tests to exclude Wilson's disease even in unsuspected cases.

Original languageEnglish
Pages (from-to)404-405
Number of pages2
JournalIdeggyógyászati szemle
Volume60
Issue number9-10
Publication statusPublished - Sep 30 2007

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Hepatolenticular Degeneration
Antipsychotic Agents
Dopamine Antagonists
Dopaminergic Neurons
Basal Ganglia
Routine Diagnostic Tests
Liver
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

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Persistent akinetic-rigid side effects of neuroleptics may indicate Wilson's disease. / Aschermann, Zsuzsanna; Szalay, F.; Schmidt, Erzsébet; Komoly, S.; Illés, Zsolt.

In: Ideggyógyászati szemle, Vol. 60, No. 9-10, 30.09.2007, p. 404-405.

Research output: Contribution to journalArticle

Aschermann, Zsuzsanna ; Szalay, F. ; Schmidt, Erzsébet ; Komoly, S. ; Illés, Zsolt. / Persistent akinetic-rigid side effects of neuroleptics may indicate Wilson's disease. In: Ideggyógyászati szemle. 2007 ; Vol. 60, No. 9-10. pp. 404-405.
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