Peroxidasins: Novel players in tissue genesis

Zalán Péterfi, Miklós Geiszt

Research output: Contribution to journalShort survey

18 Citations (Scopus)

Abstract

Stabilization of extracellular matrix by protein crosslinking is a universal and essential process in multicellular organisms. Recent findings revealed that peroxidasin, a unique heme-peroxidase, produces hypohalides to support matrix synthesis. Unexpectedly, the highly reactive and potentially damaging hypohalides mediate the formation of sulfilimine bonds between adjacent collagen IV protomers. This crosslink is a fundamental feature of basal membranes, defining peroxidasin-dependent oxidant generation and sulfilimine crosslink formation as an elemental mechanism of tissue biogenesis.

Original languageEnglish
Pages (from-to)305-307
Number of pages3
JournalTrends in Biochemical Sciences
Volume39
Issue number7
DOIs
Publication statusPublished - Jul 2014

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Keywords

  • Collagen IV
  • Extracellular matrix
  • Peroxidase
  • Peroxidasin
  • ROS
  • Sulfilimine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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