Peroxidasins: Novel players in tissue genesis

Zalán Péterfi, M. Geiszt

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Stabilization of extracellular matrix by protein crosslinking is a universal and essential process in multicellular organisms. Recent findings revealed that peroxidasin, a unique heme-peroxidase, produces hypohalides to support matrix synthesis. Unexpectedly, the highly reactive and potentially damaging hypohalides mediate the formation of sulfilimine bonds between adjacent collagen IV protomers. This crosslink is a fundamental feature of basal membranes, defining peroxidasin-dependent oxidant generation and sulfilimine crosslink formation as an elemental mechanism of tissue biogenesis.

Original languageEnglish
Pages (from-to)305-307
Number of pages3
JournalTrends in Biochemical Sciences
Volume39
Issue number7
DOIs
Publication statusPublished - 2014

Fingerprint

Tissue
Extracellular Matrix Proteins
Protein Subunits
Heme
Oxidants
Crosslinking
Peroxidase
Collagen
Stabilization
Membranes
sulfilimine
peroxidasin

Keywords

  • Collagen IV
  • Extracellular matrix
  • Peroxidase
  • Peroxidasin
  • ROS
  • Sulfilimine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Medicine(all)

Cite this

Peroxidasins : Novel players in tissue genesis. / Péterfi, Zalán; Geiszt, M.

In: Trends in Biochemical Sciences, Vol. 39, No. 7, 2014, p. 305-307.

Research output: Contribution to journalArticle

Péterfi, Zalán ; Geiszt, M. / Peroxidasins : Novel players in tissue genesis. In: Trends in Biochemical Sciences. 2014 ; Vol. 39, No. 7. pp. 305-307.
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