Permethyl monoamino β-cyclodextrin a new chiral selective agent for capillary electrophoresis

R. Iványi, L. Jicsinszky, Z. Juvancz

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Permethyl monoamino β-cyclodextrin, a new chiral selector, has been synthesized and tested as a chiral discriminating agent in capillary electrophoresis. This agent is suitable for separation of both negatively and positively charged as well as neutral enantiomers. At various concentrations of permethyl monoamino β-cyclodextrin, stable electroosmotic flow was measured in a cathodic direction. Due to the high solubilizing power and low conductivity of permethyl monoamino β-cyclodextrin efficiencies of up to 600 000 theoretical plates efficiency could be obtained. This high efficiency resulted in baseline separations of enantiomers resolved by a separation factor of only 1.009.

Original languageEnglish
Pages (from-to)166-172
Number of pages7
JournalChromatographia
Volume53
Issue number3-4
Publication statusPublished - 2001

Fingerprint

Capillary electrophoresis
Cyclodextrins
Capillary Electrophoresis
Enantiomers
Electroosmosis

Keywords

  • Capillary electrophoresis
  • Chiral separations
  • Permethyl monoamino β-cyclodex
  • Phenoxy acids
  • Trin Enantiomers of acidic, basic and neutral compounds

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry

Cite this

Permethyl monoamino β-cyclodextrin a new chiral selective agent for capillary electrophoresis. / Iványi, R.; Jicsinszky, L.; Juvancz, Z.

In: Chromatographia, Vol. 53, No. 3-4, 2001, p. 166-172.

Research output: Contribution to journalArticle

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AB - Permethyl monoamino β-cyclodextrin, a new chiral selector, has been synthesized and tested as a chiral discriminating agent in capillary electrophoresis. This agent is suitable for separation of both negatively and positively charged as well as neutral enantiomers. At various concentrations of permethyl monoamino β-cyclodextrin, stable electroosmotic flow was measured in a cathodic direction. Due to the high solubilizing power and low conductivity of permethyl monoamino β-cyclodextrin efficiencies of up to 600 000 theoretical plates efficiency could be obtained. This high efficiency resulted in baseline separations of enantiomers resolved by a separation factor of only 1.009.

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