Peritonitis in continuous ambulatory peritoneal dialysis (CAPD): A multi-centre randomized clinical trial comparing the Y connector disinfectant system to standard systems

D. N. Churchill, D. W. Taylor, S. I. Vas, D. G. Oreopoulos, K. B. Bettcher, S. S.A. Fenton, A. Fine, S. Lavoie, D. Page, G. Wu, M. L. Beecroft, R. Pemberton, N. L. Wilczynski, G. A. DeVeber, W. Williams

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Abstract

Sixty-one new continuous ambulatory peritoneal dialysis (CAPD) patients were allocated to a Y connector-disinfectant (Amuchina, Italy) and 63 to standard systems (Baxter Systems II and III) in a randomized clinical trial addressing peritonitis rates in 8 CAPD programs in 6 Canadian cities. In the Y connector-disinfectant group, 15 patients experienced 21 episodes of peritonitis in 452 patient-months or 1 per 21.53 patient-months. In the standard systems group, 30 patients experienced 47 episodes of peritonitis in 467 patient-months or 1 per 9.93 patient-months (p = 0.009). The peritonitis risk reduction was 61% (95% confidence limits 27-79%). Exit-site infections occurred in 36% of each group. Prior to the development of exit-site infection, the monthly risk for peritonitis was 3.12% for the T connector disinfectant system and 7.37% for the standard system. After an exit-site infection, these probabilities increased to 6.15% and 15.47%, respectively. Skin organisms were responsible for peritonitis in 8/21 (38%) in the Y connector-disinfectant group and 30/47 (64%) in the standard group. There were 75 days hospitalized for peritonitis in the Y connector-disinfectant group compared to 257 days for the standard group. The Y connector disinfectant system decreases the peritonitis rate through its effect on skin organisms. Exit-site infections are a major source of organisms responsible for peritonitis.

Original languageEnglish
Pages (from-to)159-163
Number of pages5
JournalPeritoneal Dialysis International
Volume9
Issue number3
Publication statusPublished - Jan 1 1989

ASJC Scopus subject areas

  • Nephrology

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    Churchill, D. N., Taylor, D. W., Vas, S. I., Oreopoulos, D. G., Bettcher, K. B., Fenton, S. S. A., Fine, A., Lavoie, S., Page, D., Wu, G., Beecroft, M. L., Pemberton, R., Wilczynski, N. L., DeVeber, G. A., & Williams, W. (1989). Peritonitis in continuous ambulatory peritoneal dialysis (CAPD): A multi-centre randomized clinical trial comparing the Y connector disinfectant system to standard systems. Peritoneal Dialysis International, 9(3), 159-163.