Perisynaptic aggrecan-based extracellular matrix coats in the human lateral geniculate body devoid of perineuronal nets

D. Lendvai, M. Morawski, G. Brückner, L. Négyessy, G. Baksa, T. Glasz, L. Patonay, R. T. Matthews, T. Arendt, A. Alpár

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The extracellular matrix surrounds different neuronal compartments in the mature nervous system. In a variety of vertebrates, most brain regions are loaded with a distinct type of extracellular matrix around the somatodendritic part of neurons, termed perineuronal nets. The present study reports that chondrotin sulfate proteoglycan-based matrix is structured differently in the human lateral geniculate body. Using various chondrotin sulfate proteoglycan-based extracellular matrix antibodies, we show that perisomatic matrix labeling is rather weak or absent, whereas dendrites are contacted by axonal coats appearing as small, oval structures. Confocal laser scanning microscopy and electron microscopy demonstrated that these typical structures are associated with synaptic loci on dendrites. Using multiple labelings, we show that different chondrotin sulfate proteoglycan components of the extracellular matrix do not associate exclusively with neuronal structures but possibly associate with glial structures as well. Finally, we confirm and extend previous findings in primates that intensity differences of various extracellular matrix markers between magno- and parvocellular layers reflect functional segregation between these layers in the human lateral geniculate body.

Original languageEnglish
Pages (from-to)376-387
Number of pages12
JournalJournal of Neuroscience Research
Volume90
Issue number2
DOIs
Publication statusPublished - Feb 2012

Fingerprint

Geniculate Bodies
Aggrecans
Extracellular Matrix
Proteoglycans
Sulfates
Dendrites
Confocal Microscopy
Neuroglia
Primates
Nervous System
Vertebrates
Electron Microscopy
Neurons
Antibodies
Brain

Keywords

  • Axonal coat
  • Perineuronal net
  • Synapse
  • Thalamus

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Perisynaptic aggrecan-based extracellular matrix coats in the human lateral geniculate body devoid of perineuronal nets. / Lendvai, D.; Morawski, M.; Brückner, G.; Négyessy, L.; Baksa, G.; Glasz, T.; Patonay, L.; Matthews, R. T.; Arendt, T.; Alpár, A.

In: Journal of Neuroscience Research, Vol. 90, No. 2, 02.2012, p. 376-387.

Research output: Contribution to journalArticle

Lendvai, D. ; Morawski, M. ; Brückner, G. ; Négyessy, L. ; Baksa, G. ; Glasz, T. ; Patonay, L. ; Matthews, R. T. ; Arendt, T. ; Alpár, A. / Perisynaptic aggrecan-based extracellular matrix coats in the human lateral geniculate body devoid of perineuronal nets. In: Journal of Neuroscience Research. 2012 ; Vol. 90, No. 2. pp. 376-387.
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