Peripheral orthopaedic surgery down-regulates hippocampal brain-derived neurotrophic factor and impairs remote memory in mouse

A. R. Fidalgo, M. Cibelli, J. P M White, I. Nagy, F. Noormohamed, L. Benzonana, M. Maze, D. Ma

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Peripheral orthopaedic surgery induces a profound inflammatory response. This includes a substantial increase in cytokines and, especially, in the level of interleukin (IL)-1β in the hippocampus, which has been shown to impair hippocampal-dependent memory in mice. We have employed two tests of contextual remote memory to demonstrate that the inflammatory response to surgical insult in mice also results in impairment of remote memory associated with prefrontal cortex (PFC). We have also found that, under the conditions presented in the social interaction test, peripheral orthopaedic surgery does not increase anxiety-like behaviour in our animal model. Although such surgery induces an increase in the level of IL-1β in the hippocampus, it fails to do so in the PFC. Peripheral orthopaedic surgery also results in a reduction in the level of hippocampal brain-derived neurotrophic factor (BDNF) and this may contribute, in part, to the memory impairment found after such surgery. Our data suggest that a reduction in the level of hippocampal BDNF and an increase in the level of hippocampal IL-1β following surgery may affect the transference of fear memory in the mouse brain.

Original languageEnglish
Pages (from-to)194-199
Number of pages6
JournalNeuroscience
Volume190
DOIs
Publication statusPublished - Sep 5 2011

Fingerprint

Long-Term Memory
Brain-Derived Neurotrophic Factor
Interleukin-1
Orthopedics
Down-Regulation
Prefrontal Cortex
Hippocampus
Interpersonal Relations
Fear
Anxiety
Animal Models
Cytokines
Brain

Keywords

  • Hippocampus
  • IL-1ß
  • PFC
  • Post-operative cognitive dysfunction
  • Remote memory
  • Surgery

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Peripheral orthopaedic surgery down-regulates hippocampal brain-derived neurotrophic factor and impairs remote memory in mouse. / Fidalgo, A. R.; Cibelli, M.; White, J. P M; Nagy, I.; Noormohamed, F.; Benzonana, L.; Maze, M.; Ma, D.

In: Neuroscience, Vol. 190, 05.09.2011, p. 194-199.

Research output: Contribution to journalArticle

Fidalgo, A. R. ; Cibelli, M. ; White, J. P M ; Nagy, I. ; Noormohamed, F. ; Benzonana, L. ; Maze, M. ; Ma, D. / Peripheral orthopaedic surgery down-regulates hippocampal brain-derived neurotrophic factor and impairs remote memory in mouse. In: Neuroscience. 2011 ; Vol. 190. pp. 194-199.
@article{ab4131d487974b08bf00b802c6ae36d2,
title = "Peripheral orthopaedic surgery down-regulates hippocampal brain-derived neurotrophic factor and impairs remote memory in mouse",
abstract = "Peripheral orthopaedic surgery induces a profound inflammatory response. This includes a substantial increase in cytokines and, especially, in the level of interleukin (IL)-1β in the hippocampus, which has been shown to impair hippocampal-dependent memory in mice. We have employed two tests of contextual remote memory to demonstrate that the inflammatory response to surgical insult in mice also results in impairment of remote memory associated with prefrontal cortex (PFC). We have also found that, under the conditions presented in the social interaction test, peripheral orthopaedic surgery does not increase anxiety-like behaviour in our animal model. Although such surgery induces an increase in the level of IL-1β in the hippocampus, it fails to do so in the PFC. Peripheral orthopaedic surgery also results in a reduction in the level of hippocampal brain-derived neurotrophic factor (BDNF) and this may contribute, in part, to the memory impairment found after such surgery. Our data suggest that a reduction in the level of hippocampal BDNF and an increase in the level of hippocampal IL-1β following surgery may affect the transference of fear memory in the mouse brain.",
keywords = "Hippocampus, IL-1{\ss}, PFC, Post-operative cognitive dysfunction, Remote memory, Surgery",
author = "Fidalgo, {A. R.} and M. Cibelli and White, {J. P M} and I. Nagy and F. Noormohamed and L. Benzonana and M. Maze and D. Ma",
year = "2011",
month = "9",
day = "5",
doi = "10.1016/j.neuroscience.2011.05.073",
language = "English",
volume = "190",
pages = "194--199",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Peripheral orthopaedic surgery down-regulates hippocampal brain-derived neurotrophic factor and impairs remote memory in mouse

AU - Fidalgo, A. R.

AU - Cibelli, M.

AU - White, J. P M

AU - Nagy, I.

AU - Noormohamed, F.

AU - Benzonana, L.

AU - Maze, M.

AU - Ma, D.

PY - 2011/9/5

Y1 - 2011/9/5

N2 - Peripheral orthopaedic surgery induces a profound inflammatory response. This includes a substantial increase in cytokines and, especially, in the level of interleukin (IL)-1β in the hippocampus, which has been shown to impair hippocampal-dependent memory in mice. We have employed two tests of contextual remote memory to demonstrate that the inflammatory response to surgical insult in mice also results in impairment of remote memory associated with prefrontal cortex (PFC). We have also found that, under the conditions presented in the social interaction test, peripheral orthopaedic surgery does not increase anxiety-like behaviour in our animal model. Although such surgery induces an increase in the level of IL-1β in the hippocampus, it fails to do so in the PFC. Peripheral orthopaedic surgery also results in a reduction in the level of hippocampal brain-derived neurotrophic factor (BDNF) and this may contribute, in part, to the memory impairment found after such surgery. Our data suggest that a reduction in the level of hippocampal BDNF and an increase in the level of hippocampal IL-1β following surgery may affect the transference of fear memory in the mouse brain.

AB - Peripheral orthopaedic surgery induces a profound inflammatory response. This includes a substantial increase in cytokines and, especially, in the level of interleukin (IL)-1β in the hippocampus, which has been shown to impair hippocampal-dependent memory in mice. We have employed two tests of contextual remote memory to demonstrate that the inflammatory response to surgical insult in mice also results in impairment of remote memory associated with prefrontal cortex (PFC). We have also found that, under the conditions presented in the social interaction test, peripheral orthopaedic surgery does not increase anxiety-like behaviour in our animal model. Although such surgery induces an increase in the level of IL-1β in the hippocampus, it fails to do so in the PFC. Peripheral orthopaedic surgery also results in a reduction in the level of hippocampal brain-derived neurotrophic factor (BDNF) and this may contribute, in part, to the memory impairment found after such surgery. Our data suggest that a reduction in the level of hippocampal BDNF and an increase in the level of hippocampal IL-1β following surgery may affect the transference of fear memory in the mouse brain.

KW - Hippocampus

KW - IL-1ß

KW - PFC

KW - Post-operative cognitive dysfunction

KW - Remote memory

KW - Surgery

UR - http://www.scopus.com/inward/record.url?scp=80051589177&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80051589177&partnerID=8YFLogxK

U2 - 10.1016/j.neuroscience.2011.05.073

DO - 10.1016/j.neuroscience.2011.05.073

M3 - Article

VL - 190

SP - 194

EP - 199

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

ER -