Peripheral nerve injury influences the disinhibition induced by focal ischaemia in the rat motor cortex

T. Farkas, Eniko Racekova, Z. Kis, Szatmár Horváth, Jozef Burda, Jan Galik, J. Toldi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Photothrombotic lesions were produced in the rat primary motor cortex, and the brain excitability was assessed in a paired-pulse stimulation protocol by transcranial recording, in parallel at 16 points of the frontal cortex, including the insulted and the surrounding areas. The cortical lesion reduced the inhibition in the extended frontal cortex, with a delay of a few minutes. Unilateral facial nerve transection, however, accelerated the widespread disinhibition. Although the mechanism is not clear in detail, both peripheral and central injury-induced disinhibition may have a significant impact on the recovery of the function.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalNeuroscience Letters
Volume342
Issue number1-2
DOIs
Publication statusPublished - May 15 2003

Fingerprint

Peripheral Nerve Injuries
Motor Cortex
Frontal Lobe
Ischemia
Recovery of Function
Facial Nerve
Wounds and Injuries
Brain

Keywords

  • Cortical disinhibition
  • Facial nerve
  • Focal ischaemia
  • Motor cortex
  • Nerve injury
  • Rose Bengal

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Peripheral nerve injury influences the disinhibition induced by focal ischaemia in the rat motor cortex. / Farkas, T.; Racekova, Eniko; Kis, Z.; Horváth, Szatmár; Burda, Jozef; Galik, Jan; Toldi, J.

In: Neuroscience Letters, Vol. 342, No. 1-2, 15.05.2003, p. 49-52.

Research output: Contribution to journalArticle

Farkas, T. ; Racekova, Eniko ; Kis, Z. ; Horváth, Szatmár ; Burda, Jozef ; Galik, Jan ; Toldi, J. / Peripheral nerve injury influences the disinhibition induced by focal ischaemia in the rat motor cortex. In: Neuroscience Letters. 2003 ; Vol. 342, No. 1-2. pp. 49-52.
@article{fa7056767a954335b6e63bccabc40b5e,
title = "Peripheral nerve injury influences the disinhibition induced by focal ischaemia in the rat motor cortex",
abstract = "Photothrombotic lesions were produced in the rat primary motor cortex, and the brain excitability was assessed in a paired-pulse stimulation protocol by transcranial recording, in parallel at 16 points of the frontal cortex, including the insulted and the surrounding areas. The cortical lesion reduced the inhibition in the extended frontal cortex, with a delay of a few minutes. Unilateral facial nerve transection, however, accelerated the widespread disinhibition. Although the mechanism is not clear in detail, both peripheral and central injury-induced disinhibition may have a significant impact on the recovery of the function.",
keywords = "Cortical disinhibition, Facial nerve, Focal ischaemia, Motor cortex, Nerve injury, Rose Bengal",
author = "T. Farkas and Eniko Racekova and Z. Kis and Szatm{\'a}r Horv{\'a}th and Jozef Burda and Jan Galik and J. Toldi",
year = "2003",
month = "5",
day = "15",
doi = "10.1016/S0304-3940(03)00230-1",
language = "English",
volume = "342",
pages = "49--52",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

TY - JOUR

T1 - Peripheral nerve injury influences the disinhibition induced by focal ischaemia in the rat motor cortex

AU - Farkas, T.

AU - Racekova, Eniko

AU - Kis, Z.

AU - Horváth, Szatmár

AU - Burda, Jozef

AU - Galik, Jan

AU - Toldi, J.

PY - 2003/5/15

Y1 - 2003/5/15

N2 - Photothrombotic lesions were produced in the rat primary motor cortex, and the brain excitability was assessed in a paired-pulse stimulation protocol by transcranial recording, in parallel at 16 points of the frontal cortex, including the insulted and the surrounding areas. The cortical lesion reduced the inhibition in the extended frontal cortex, with a delay of a few minutes. Unilateral facial nerve transection, however, accelerated the widespread disinhibition. Although the mechanism is not clear in detail, both peripheral and central injury-induced disinhibition may have a significant impact on the recovery of the function.

AB - Photothrombotic lesions were produced in the rat primary motor cortex, and the brain excitability was assessed in a paired-pulse stimulation protocol by transcranial recording, in parallel at 16 points of the frontal cortex, including the insulted and the surrounding areas. The cortical lesion reduced the inhibition in the extended frontal cortex, with a delay of a few minutes. Unilateral facial nerve transection, however, accelerated the widespread disinhibition. Although the mechanism is not clear in detail, both peripheral and central injury-induced disinhibition may have a significant impact on the recovery of the function.

KW - Cortical disinhibition

KW - Facial nerve

KW - Focal ischaemia

KW - Motor cortex

KW - Nerve injury

KW - Rose Bengal

UR - http://www.scopus.com/inward/record.url?scp=0242500801&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242500801&partnerID=8YFLogxK

U2 - 10.1016/S0304-3940(03)00230-1

DO - 10.1016/S0304-3940(03)00230-1

M3 - Article

C2 - 12727315

AN - SCOPUS:0242500801

VL - 342

SP - 49

EP - 52

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1-2

ER -