Peripheral inflammatory activation after hippocampus irradiation in the rat

Tünde Tokés, Gabriella Varga, Dénes Garab, Zoltán Nagy, Gábor Fekete, Eszter Tuboly, Imola Plangár, Imola Mán, Rita Emília Szabó, Zoltán Szabó, Gábor Volford, Miklós Ghyczy, József Kaszaki, Mihály Boros, Katalin Hideghéty

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5 Citations (Scopus)


Purpose: To detect the possible biochemical signs of inflammatory activation in the peripheral circulation in a rodent model of hippocampus irradiation, and to examine the effects of L-alpha-glycerylphosphorylcholine (GPC) in this experimental protocol. Materials and methods: Anesthetized Sprague-Dawley rats were subjected to 40 Gy cobalt irradiation of both hemispheres of the hippocampus, with or without GPC treatment (50 mg/kg intravenously (i.v.), 5 min before the irradiation, n = 6, each). A third group (n = 6) served as saline-treated control. Blood samples were obtained 3 h after the end of irradiation in order to examine the changes in plasma histamine, tumor necrosis factor-alpha (TNF-α), interleukin 1-beta, interleukin 6 (IL-6) and interleukin 10 (IL-10); liver tissue samples were taken to determine adenosine triphosphate (ATP) concentrations. Results: The hepatic ATP levels were significantly declined, while plasma concentrations of circulating TNF-α, IL-6, IL-10 and histamine were significantly increased after hippocampus irradiation. GPC treatment significantly reduced the irradiation-induced release of cytokines and histamine, and the liver ATP level was maintained at the control value. Conclusions: Targeted brain irradiation produced measurable pro-and anti-inflammatory cytokine changes in the systemic circulation. GPC supplementation provides significant protection against irradiation-induced peripheral pro-inflammatory activation and ATP depletion.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalInternational Journal of Radiation Biology
Issue number1
Publication statusPublished - Jan 2014


  • ATP
  • Brain irradiation
  • Cytokines
  • L-alpha-glycerylphosphorylcholine
  • Radioprotection
  • TNF-alpha

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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    Tokés, T., Varga, G., Garab, D., Nagy, Z., Fekete, G., Tuboly, E., Plangár, I., Mán, I., Szabó, R. E., Szabó, Z., Volford, G., Ghyczy, M., Kaszaki, J., Boros, M., & Hideghéty, K. (2014). Peripheral inflammatory activation after hippocampus irradiation in the rat. International Journal of Radiation Biology, 90(1), 1-6.