Peripheral CD4+ cell prevalence and pleuropulmonary manifestations in systemic lupus erythematosus patients

Krisztina Vincze, Zsuzsanna Kovats, Aron Cseh, Krisztina Pasti, E. Kiss, Anna Polgar, B. Vásárhelyi, Attila J. Szabo, Aniko Bohacs, L. Tamási, G. Losonczy, V. Müller

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Introduction Systemic lupus erythematosus (SLE) is an autoimmune disease involving several organs, including the lungs. Previous results confirmed changes of peripheral T cell subsets in lupus patients; however no data are available about their possible relationship with pulmonary involvement. Objective To determine pulmonary manifestations and potential relationship in changes of peripheral CD4+ T cell subsets. Methods Patients with SLE (N = 28) were enrolled in complex pulmonary examination. Patients were divided into groups with pleuropulmonary manifestations (SLEpulm N = 13 age: 44.9 ± 3.3 years, female: male = 11:2) or without (SLEc N = 15 age: 27.2 ± 3.7 years, female: male = 12:3). Peripheral blood was taken for T helper (Th)1, Th2, Th17, CD4+CD25hi+ and regulatory T (Treg: CD4+CD25hi+ CD127-) cell analysis from SLE patients and healthy volunteers (controls, N = 40). Results SLEpulm patients were older, had more pulmonary symptoms and significantly decreased pO2 as compared to SLEc group. Ventilatory disorder was present in 92% of SLEpulm patients, with significantly decreased lung volumes, signs of airway involvement and decrease in DLco. Significant increase in Th1/Th2, while decrease in Th17/Treg ratios was present in all SLE compared to controls. In SLEpulm CD4+CD25hi+ subset without changes in Treg number was significantly increased as compared to SLEc and this subgroup of T cell showed significant positive correlation with dynamic lung function parameters and DLco (p <0.05). Conclusion In lupus patients pleuropulmonary manifestations are prevalent and lung function and blood gas measurements should be regularly performed in the daily clinical assessment. Significant increase of activated CD4+CD25hi+ T cells, but not Treg is associated with decreased lung function parameters in SLEpulm patients.

Original languageEnglish
Pages (from-to)766-774
Number of pages9
JournalRespiratory Medicine
Volume108
Issue number5
DOIs
Publication statusPublished - 2014

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Systemic Lupus Erythematosus
Lung
T-Lymphocyte Subsets
T-Lymphocytes
Autoimmune Diseases
Healthy Volunteers
Gases

Keywords

  • Lung
  • Lung function
  • Systemic lupus erythematosus
  • T cells

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Medicine(all)

Cite this

Peripheral CD4+ cell prevalence and pleuropulmonary manifestations in systemic lupus erythematosus patients. / Vincze, Krisztina; Kovats, Zsuzsanna; Cseh, Aron; Pasti, Krisztina; Kiss, E.; Polgar, Anna; Vásárhelyi, B.; Szabo, Attila J.; Bohacs, Aniko; Tamási, L.; Losonczy, G.; Müller, V.

In: Respiratory Medicine, Vol. 108, No. 5, 2014, p. 766-774.

Research output: Contribution to journalArticle

Vincze, Krisztina ; Kovats, Zsuzsanna ; Cseh, Aron ; Pasti, Krisztina ; Kiss, E. ; Polgar, Anna ; Vásárhelyi, B. ; Szabo, Attila J. ; Bohacs, Aniko ; Tamási, L. ; Losonczy, G. ; Müller, V. / Peripheral CD4+ cell prevalence and pleuropulmonary manifestations in systemic lupus erythematosus patients. In: Respiratory Medicine. 2014 ; Vol. 108, No. 5. pp. 766-774.
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abstract = "Introduction Systemic lupus erythematosus (SLE) is an autoimmune disease involving several organs, including the lungs. Previous results confirmed changes of peripheral T cell subsets in lupus patients; however no data are available about their possible relationship with pulmonary involvement. Objective To determine pulmonary manifestations and potential relationship in changes of peripheral CD4+ T cell subsets. Methods Patients with SLE (N = 28) were enrolled in complex pulmonary examination. Patients were divided into groups with pleuropulmonary manifestations (SLEpulm N = 13 age: 44.9 ± 3.3 years, female: male = 11:2) or without (SLEc N = 15 age: 27.2 ± 3.7 years, female: male = 12:3). Peripheral blood was taken for T helper (Th)1, Th2, Th17, CD4+CD25hi+ and regulatory T (Treg: CD4+CD25hi+ CD127-) cell analysis from SLE patients and healthy volunteers (controls, N = 40). Results SLEpulm patients were older, had more pulmonary symptoms and significantly decreased pO2 as compared to SLEc group. Ventilatory disorder was present in 92{\%} of SLEpulm patients, with significantly decreased lung volumes, signs of airway involvement and decrease in DLco. Significant increase in Th1/Th2, while decrease in Th17/Treg ratios was present in all SLE compared to controls. In SLEpulm CD4+CD25hi+ subset without changes in Treg number was significantly increased as compared to SLEc and this subgroup of T cell showed significant positive correlation with dynamic lung function parameters and DLco (p <0.05). Conclusion In lupus patients pleuropulmonary manifestations are prevalent and lung function and blood gas measurements should be regularly performed in the daily clinical assessment. Significant increase of activated CD4+CD25hi+ T cells, but not Treg is associated with decreased lung function parameters in SLEpulm patients.",
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T1 - Peripheral CD4+ cell prevalence and pleuropulmonary manifestations in systemic lupus erythematosus patients

AU - Vincze, Krisztina

AU - Kovats, Zsuzsanna

AU - Cseh, Aron

AU - Pasti, Krisztina

AU - Kiss, E.

AU - Polgar, Anna

AU - Vásárhelyi, B.

AU - Szabo, Attila J.

AU - Bohacs, Aniko

AU - Tamási, L.

AU - Losonczy, G.

AU - Müller, V.

PY - 2014

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N2 - Introduction Systemic lupus erythematosus (SLE) is an autoimmune disease involving several organs, including the lungs. Previous results confirmed changes of peripheral T cell subsets in lupus patients; however no data are available about their possible relationship with pulmonary involvement. Objective To determine pulmonary manifestations and potential relationship in changes of peripheral CD4+ T cell subsets. Methods Patients with SLE (N = 28) were enrolled in complex pulmonary examination. Patients were divided into groups with pleuropulmonary manifestations (SLEpulm N = 13 age: 44.9 ± 3.3 years, female: male = 11:2) or without (SLEc N = 15 age: 27.2 ± 3.7 years, female: male = 12:3). Peripheral blood was taken for T helper (Th)1, Th2, Th17, CD4+CD25hi+ and regulatory T (Treg: CD4+CD25hi+ CD127-) cell analysis from SLE patients and healthy volunteers (controls, N = 40). Results SLEpulm patients were older, had more pulmonary symptoms and significantly decreased pO2 as compared to SLEc group. Ventilatory disorder was present in 92% of SLEpulm patients, with significantly decreased lung volumes, signs of airway involvement and decrease in DLco. Significant increase in Th1/Th2, while decrease in Th17/Treg ratios was present in all SLE compared to controls. In SLEpulm CD4+CD25hi+ subset without changes in Treg number was significantly increased as compared to SLEc and this subgroup of T cell showed significant positive correlation with dynamic lung function parameters and DLco (p <0.05). Conclusion In lupus patients pleuropulmonary manifestations are prevalent and lung function and blood gas measurements should be regularly performed in the daily clinical assessment. Significant increase of activated CD4+CD25hi+ T cells, but not Treg is associated with decreased lung function parameters in SLEpulm patients.

AB - Introduction Systemic lupus erythematosus (SLE) is an autoimmune disease involving several organs, including the lungs. Previous results confirmed changes of peripheral T cell subsets in lupus patients; however no data are available about their possible relationship with pulmonary involvement. Objective To determine pulmonary manifestations and potential relationship in changes of peripheral CD4+ T cell subsets. Methods Patients with SLE (N = 28) were enrolled in complex pulmonary examination. Patients were divided into groups with pleuropulmonary manifestations (SLEpulm N = 13 age: 44.9 ± 3.3 years, female: male = 11:2) or without (SLEc N = 15 age: 27.2 ± 3.7 years, female: male = 12:3). Peripheral blood was taken for T helper (Th)1, Th2, Th17, CD4+CD25hi+ and regulatory T (Treg: CD4+CD25hi+ CD127-) cell analysis from SLE patients and healthy volunteers (controls, N = 40). Results SLEpulm patients were older, had more pulmonary symptoms and significantly decreased pO2 as compared to SLEc group. Ventilatory disorder was present in 92% of SLEpulm patients, with significantly decreased lung volumes, signs of airway involvement and decrease in DLco. Significant increase in Th1/Th2, while decrease in Th17/Treg ratios was present in all SLE compared to controls. In SLEpulm CD4+CD25hi+ subset without changes in Treg number was significantly increased as compared to SLEc and this subgroup of T cell showed significant positive correlation with dynamic lung function parameters and DLco (p <0.05). Conclusion In lupus patients pleuropulmonary manifestations are prevalent and lung function and blood gas measurements should be regularly performed in the daily clinical assessment. Significant increase of activated CD4+CD25hi+ T cells, but not Treg is associated with decreased lung function parameters in SLEpulm patients.

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