Peripheral blood lymphocyte subpopulations in children with juvenile chronic arthritis.

K. Nagy, L. Kassay, E. Berkes, L. Velkey

Research output: Contribution to journalArticle

Abstract

Peripheral blood lymphocyte subset levels were analyzed in 28 patients with active, polyarticular, juvenile chronic arthritis and in 12 healthy control children. The patients with a similar treatment were divided into two groups, at the beginning of disease and after five years' course. Ten children with juvenile chronic arthritis were treated by glucocorticosteroid. After five years the percentage of active T cells, T suppressor cells and active/total T cells ratio were significantly elevated and there was a decrease in the T4/T8 ratio. Glucocorticosteroids increased the proportion of active T cells but did not change the percentage of other lymphocyte subsets. It is concluded that during the course of disease a drug-induced or spontaneous process appears which corrects the initial immunological disturbance.

Original languageEnglish
Pages (from-to)251-261
Number of pages11
JournalActa Paediatrica Hungarica
Volume30
Issue number2
Publication statusPublished - 1990

Fingerprint

Juvenile Arthritis
Lymphocyte Subsets
T-Lymphocytes
CD4-CD8 Ratio
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Peripheral blood lymphocyte subpopulations in children with juvenile chronic arthritis. / Nagy, K.; Kassay, L.; Berkes, E.; Velkey, L.

In: Acta Paediatrica Hungarica, Vol. 30, No. 2, 1990, p. 251-261.

Research output: Contribution to journalArticle

Nagy, K. ; Kassay, L. ; Berkes, E. ; Velkey, L. / Peripheral blood lymphocyte subpopulations in children with juvenile chronic arthritis. In: Acta Paediatrica Hungarica. 1990 ; Vol. 30, No. 2. pp. 251-261.
@article{586137cac2694677b0c07a70bf4b25b7,
title = "Peripheral blood lymphocyte subpopulations in children with juvenile chronic arthritis.",
abstract = "Peripheral blood lymphocyte subset levels were analyzed in 28 patients with active, polyarticular, juvenile chronic arthritis and in 12 healthy control children. The patients with a similar treatment were divided into two groups, at the beginning of disease and after five years' course. Ten children with juvenile chronic arthritis were treated by glucocorticosteroid. After five years the percentage of active T cells, T suppressor cells and active/total T cells ratio were significantly elevated and there was a decrease in the T4/T8 ratio. Glucocorticosteroids increased the proportion of active T cells but did not change the percentage of other lymphocyte subsets. It is concluded that during the course of disease a drug-induced or spontaneous process appears which corrects the initial immunological disturbance.",
author = "K. Nagy and L. Kassay and E. Berkes and L. Velkey",
year = "1990",
language = "English",
volume = "30",
pages = "251--261",
journal = "European Journal of Pediatrics",
issn = "0340-6199",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - Peripheral blood lymphocyte subpopulations in children with juvenile chronic arthritis.

AU - Nagy, K.

AU - Kassay, L.

AU - Berkes, E.

AU - Velkey, L.

PY - 1990

Y1 - 1990

N2 - Peripheral blood lymphocyte subset levels were analyzed in 28 patients with active, polyarticular, juvenile chronic arthritis and in 12 healthy control children. The patients with a similar treatment were divided into two groups, at the beginning of disease and after five years' course. Ten children with juvenile chronic arthritis were treated by glucocorticosteroid. After five years the percentage of active T cells, T suppressor cells and active/total T cells ratio were significantly elevated and there was a decrease in the T4/T8 ratio. Glucocorticosteroids increased the proportion of active T cells but did not change the percentage of other lymphocyte subsets. It is concluded that during the course of disease a drug-induced or spontaneous process appears which corrects the initial immunological disturbance.

AB - Peripheral blood lymphocyte subset levels were analyzed in 28 patients with active, polyarticular, juvenile chronic arthritis and in 12 healthy control children. The patients with a similar treatment were divided into two groups, at the beginning of disease and after five years' course. Ten children with juvenile chronic arthritis were treated by glucocorticosteroid. After five years the percentage of active T cells, T suppressor cells and active/total T cells ratio were significantly elevated and there was a decrease in the T4/T8 ratio. Glucocorticosteroids increased the proportion of active T cells but did not change the percentage of other lymphocyte subsets. It is concluded that during the course of disease a drug-induced or spontaneous process appears which corrects the initial immunological disturbance.

UR - http://www.scopus.com/inward/record.url?scp=0025657510&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025657510&partnerID=8YFLogxK

M3 - Article

C2 - 2248804

AN - SCOPUS:0025657510

VL - 30

SP - 251

EP - 261

JO - European Journal of Pediatrics

JF - European Journal of Pediatrics

SN - 0340-6199

IS - 2

ER -