Peripheral blood galectin-1-expressing T and natural killer cells in normal pregnancy and preeclampsia

Attila Molvarec, Sandra M. Blois, Balázs Stenczer, Gergely Toldi, Irene Tirado-Gonzalez, Mika Ito, Tomoko Shima, Satoshi Yoneda, Barna Vásárhelyi, János Rigó, Shigeru Saito

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The purpose of this study was to determine whether the proportion of galectin-1-expressing peripheral blood T and NK cells is altered in normal pregnancy and preeclampsia (PE). We also examined whether circulating levels of galectin-1 and anti-galectin-1 autoantibodies are affected in PE. Seventy preeclamptic patients, 75 healthy pregnant and 21 healthy non-pregnant women were involved in this study. Serum galectin-1 and anti-galectin-1 autoantibody levels were measured by ELISA. Intracellular galectin-1 expression of lymphocytes was determined with flow cytometry. Serum galectin-1 and anti-galectin-1 IgG levels did not differ significantly between the healthy pregnant and the PE group. In healthy pregnant women, significantly higher percentage of T and NK cells expressed gal-1 in their cytoplasma than in healthy non-pregnant women. However, the proportion of galectin-1-expressing peripheral blood T and NK cells was markedly decreased in PE compared to normal pregnancy, which might contribute to the activation of innate and acquired immune cells.

Original languageEnglish
Pages (from-to)48-56
Number of pages9
JournalClinical Immunology
Volume139
Issue number1
DOIs
Publication statusPublished - Apr 1 2011

Keywords

  • Angiogenic factor
  • Autoantibody
  • Galectin-1
  • Inflammation
  • Lymphocyte
  • Preeclampsia
  • Pregnancy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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