Peripheral B-lymphocyte markers and function in IgA nephropathy

T. Magyarlaki, J. C. Davin, E. Szabados, B. Kocsis, J. Nagy

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Peripheral blood B-lymphocyte markers and functions were observed in 21 patients with IgA nephropathy (IgA NP) and in 16 controls. IgA NP B lymphocytes expressed significantly higher positivity with Leu 1 (CD 5) monoclonal antibody than controls. CD 5 positive B lymphocytes are thought to be a distinct subset of the B cells (autoregulatory B lymphocytes) inducible in IgA NP by lipopolysaccharide (LPS) stimulation parallel to the higher expression of surface IgM heavy chain positivity. The activated state of IgA NP B lymphocytes has been proved by their higher OKIa (HLA-DR) positivities but lower IOB1a (CD21, C3d-receptor) and decreased IgG-F(c)-receptor (ox-rosette) expression. IgA NP B lymphocytes showed a higher IgA but also IgG and IgM polyclonal immunoglobulin production than control B lymphocytes in co-cultures with T lymphocytes. Not only regulatory T lymphocyte subsets but also serum derived from IgA NP patients stimulated the immunoglobulin production of IgA NP B cells.

Original languageEnglish
Pages (from-to)123-129
Number of pages7
JournalClinical Nephrology
Volume33
Issue number3
Publication statusPublished - Jan 1 1990

Keywords

  • CD 5 positivity
  • Ig production
  • IgA nephropathy
  • LPS stimulation
  • activated B lymphocytes

ASJC Scopus subject areas

  • Nephrology

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