Peripheral B-lymphocyte markers and function in IgA nephropathy

T. Magyarlaki, J. C. Davin, E. Szabados, B. Kocsis, J. Nagy

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Peripheral blood B-lymphocyte markers and functions were observed in 21 patients with IgA nephropathy (IgA NP) and in 16 controls. IgA NP B lymphocytes expressed significantly higher positivity with Leu 1 (CD 5) monoclonal antibody than controls. CD 5 positive B lymphocytes are thought to be a distinct subset of the B cells (autoregulatory B lymphocytes) inducible in IgA NP by lipopolysaccharide (LPS) stimulation parallel to the higher expression of surface IgM heavy chain positivity. The activated state of IgA NP B lymphocytes has been proved by their higher OKIa (HLA-DR) positivities but lower IOB1a (CD21, C3d-receptor) and decreased IgG-F(c)-receptor (ox-rosette) expression. IgA NP B lymphocytes showed a higher IgA but also IgG and IgM polyclonal immunoglobulin production than control B lymphocytes in co-cultures with T lymphocytes. Not only regulatory T lymphocyte subsets but also serum derived from IgA NP patients stimulated the immunoglobulin production of IgA NP B cells.

Original languageEnglish
Pages (from-to)123-129
Number of pages7
JournalClinical Nephrology
Volume33
Issue number3
Publication statusPublished - 1990

Fingerprint

Immunoglobulin A
B-Lymphocytes
Immunoglobulin M
Immunoglobulins
Immunoglobulin G
Complement 3d Receptors
B-Lymphocyte Subsets
T-Lymphocyte Subsets
HLA-DR Antigens
Regulatory T-Lymphocytes
Coculture Techniques
Lipopolysaccharides
Monoclonal Antibodies
T-Lymphocytes
Serum

Keywords

  • activated B lymphocytes
  • CD 5 positivity
  • Ig production
  • IgA nephropathy
  • LPS stimulation

ASJC Scopus subject areas

  • Nephrology

Cite this

Peripheral B-lymphocyte markers and function in IgA nephropathy. / Magyarlaki, T.; Davin, J. C.; Szabados, E.; Kocsis, B.; Nagy, J.

In: Clinical Nephrology, Vol. 33, No. 3, 1990, p. 123-129.

Research output: Contribution to journalArticle

Magyarlaki, T, Davin, JC, Szabados, E, Kocsis, B & Nagy, J 1990, 'Peripheral B-lymphocyte markers and function in IgA nephropathy', Clinical Nephrology, vol. 33, no. 3, pp. 123-129.
Magyarlaki, T. ; Davin, J. C. ; Szabados, E. ; Kocsis, B. ; Nagy, J. / Peripheral B-lymphocyte markers and function in IgA nephropathy. In: Clinical Nephrology. 1990 ; Vol. 33, No. 3. pp. 123-129.
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