Periparturient insulin secretion and whole-body insulin responsiveness in dairy cows showing various forms of ketone pattern with or without puerperal metritis

M. Kerestes, V. Faigl, M. Kulcsár, O. Balogh, J. Földi, H. Fébel, Y. Chilliard, G. Huszenicza

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

To study the effect of time and different forms of hyperketonemia, with or without puerperal metritis, on insulin and glucose responses, 31 Holstein cows were subjected to glucose (GTT) and insulin tolerance tests (ITT) between 18 and 22 d before, and on days 7 and 60-70 after calving. Plasma concentrations of beta-hydroxybutyrate (BHB), nonesterified fatty acids, glucose, insulin, insulin-like growth factor I and leptin were measured from 18 d before until 70 d after calving. The revised quick insulin sensitivity index (RQUICKI) was calculated at each time point. First postpartum (PP) ovulation was monitored by milk progesterone. Based on BHB patterns and clinical findings, animals were classified as 1) Normoketonemic (NK, n = 9); 2) Transiently hyperketonemic (tHK, n = 7); 3) Continuously HK (cHK, n = 7); and 4) Continuously HK, with signs of puerperal metritis (cHK + PM, n = 6). Insulin area under the curve (AUC) and insulin response to glucose were significantly lower in the early PP period than in late-pregnancy (P <0.001), and on day 7 after calving in cHK and cHK + PM groups compared to NK and tHK groups (P <0.001). On day 7, insulin stimulated a decrease in plasma glucose in cHK, cHK + PMthan NK, and tHK groups. Normoketonemic cows (group 1) ovulated earlier than all other groups (P = 0.002). There was no correlation between GTT and ITT variables and the RQUICKI. Time had a significant effect on RQUICKI. Long-term hyperketonemia, especially combined with puerperal metritis, interacts with secretion of insulin and whole-body IR, and results in a significant delay in PP ovarian activity in dairy cows.

Original languageEnglish
Pages (from-to)250-261
Number of pages12
JournalDomestic Animal Endocrinology
Volume37
Issue number4
DOIs
Publication statusPublished - Nov 2009

Fingerprint

insulin secretion
endometritis
ketones
Ketones
insulin
dairy cows
Insulin
hyperketonemia
insulin resistance
3-hydroxybutyric acid
calving
glucose
Glucose
Postpartum Period
Insulin Resistance
3-Hydroxybutyric Acid
cows
postpartum period
insulin-like growth factor I
leptin

Keywords

  • Insulin
  • Insulin resistance
  • Ketosis
  • Postpartum dairy cow
  • Puerperal metritis

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Endocrinology
  • Food Animals

Cite this

Periparturient insulin secretion and whole-body insulin responsiveness in dairy cows showing various forms of ketone pattern with or without puerperal metritis. / Kerestes, M.; Faigl, V.; Kulcsár, M.; Balogh, O.; Földi, J.; Fébel, H.; Chilliard, Y.; Huszenicza, G.

In: Domestic Animal Endocrinology, Vol. 37, No. 4, 11.2009, p. 250-261.

Research output: Contribution to journalArticle

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