Periparturient endocrine and metabolic changes in healthy cows and in cows affected by mastitis.

J. A. Nikolić, M. Kulcsár, L. Kátai, O. Nedić, S. Jánosi, G. Huszenicza

Research output: Contribution to journalArticle

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Abstract

Transition from pregnancy to lactation in dairy cows involves considerable metabolic adaptation. Additional stress is incurred during infections such as periparturient mastitis. Multiparous Holstein-Friesian cows kept under normal production conditions (n = 15) were used to evaluate changes in circulating metabolite and hormone concentrations from 5 days before to 5 days after calving. Insulin-like growth factor binding protein (IGFBP) profiles were also monitored. Marked time-related changes were observed for plasma thyroid hormone, IGF, cortisol, insulin, beta-hydroxybutyrate (BHB) and non-esterified fatty acid (NEFA) concentrations but not for plasma leptin. A decrease in IGF-II concentration and maximal intensity of the putative IGFBP-1 band occurred at parturition. When compared with the five healthy cows,low IGF-II levels were prolonged to day 2 post-partum in five cows with Escherichia coli-associated mastitis. However, marked decreases in IGFBP-2 band intensity were evident only in two of the four cases examined. Individual total ligand (IGF-I + IGF-II) concentration and IGFBP pattern prepartum were largely regained 5 days post-partum in all cows. Hormone and metabolite concentrations in the two cows with Staphylococcus aureus-associated mastitis were very similar to those in the five healthy cows. Plasma thyroxine (T4) was lower 2 days prepartum in the cows, which later developed Gram-negative mastitis. Multiregression analysis showed that variance in T4 concentration was significantly and independently associated with triiodothyronine (T3) and IGF-I positively and with cortisol negatively (R2 = 0.648). This study confirms the close inter-relationship between the thyroid hormone and IGF axes in cattle and indicates possible effects of Gram-negative mastitis infection on IGF-II metabolism.

Original languageEnglish
Pages (from-to)22-29
Number of pages8
JournalJournal of Veterinary Medicine, Series A
Volume50
Issue number1
Publication statusPublished - Feb 2003

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Mastitis
Insulin-Like Growth Factor II
mastitis
insulin-like growth factor II
insulin-like growth factor binding proteins
cows
Insulin-Like Growth Factor Binding Proteins
Insulin-Like Growth Factor I
Thyroid Hormones
Hydrocortisone
L-thyroxine
triiodothyronine
thyroid hormones
insulin-like growth factor I
Hormones
Insulin-Like Growth Factor Binding Protein 2
Insulin-Like Growth Factor Binding Protein 1
cortisol
3-Hydroxybutyric Acid
Triiodothyronine

ASJC Scopus subject areas

  • veterinary(all)
  • Pathology and Forensic Medicine

Cite this

Periparturient endocrine and metabolic changes in healthy cows and in cows affected by mastitis. / Nikolić, J. A.; Kulcsár, M.; Kátai, L.; Nedić, O.; Jánosi, S.; Huszenicza, G.

In: Journal of Veterinary Medicine, Series A, Vol. 50, No. 1, 02.2003, p. 22-29.

Research output: Contribution to journalArticle

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