Perioperative time course of matrix metalloproteinase-9 (MMP-9), its tissue inhibitor TIMP-1 & S100B protein in carotid surgery

Bálint Nagy, Gábor Woth, Ákos Mérei, Lilla Nagy, J. Lantos, Gábor Menyhei, L. Bogár, Diána Mühl

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background & objectives, Ischaemic stroke is a life burdening disease for which carotid endarterectomy (CEA) is considered a gold standard intervention. Pro-inflammatory markers like matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) and S-100 Beta (S100B) may have a role in the early inflammation and cognitive decline following CEA. This study was aimed to describe the perioperative time courses and correlations between of MMP-9, TIMP-1 and S100B following CEA. Methods, Fifty four patients scheduled for CEA were enrolled. Blood samples were collected at four time points, T1, preoperative, T2, 60 min after cross-clamp release, T3, first postoperative morning, T4, third postoperative morning. Twenty atherosclerotic patients were included as controls. Plasma MMP-9, TIMP-1 and S100B levels were estimated by ELISA. Results, TIMP-1 was decreased significantly in the CEA group (P1-4 in the CEA group (P3 compared to T1 (P2 and T3 (P2 and decreased on T3-4 compared to T1. Interpretation & conclusions, Our study provides information on the dynamic changes of MMP-9-TIMP-1 system and S100B in the perioperative period. Preoperative reduction of TIMP-1 might be predictive for shunt requirement but future studies are required for verification.

Original languageEnglish
Pages (from-to)220-226
Number of pages7
JournalIndian Journal of Medical Research
Volume143
Issue numberFEBRUARY
DOIs
Publication statusPublished - Feb 1 2016

Keywords

  • Carotid surgery
  • Matrix metalloproteinase
  • MMP-9
  • POCD
  • S100B
  • TIMP-1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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