Perinatal polyunstaurated fatty acids supplementation causes alterations in fuel homeostasis in adult male rats but does not offer resistance against STZ-induced diabetes

G. Van Dijk, A. Kacsndi, D. E. Kbor-Nyakas, E. Hgyes, C. Nyakas

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Maternal factors can have major imprinting effects on homeostatic mechanisms in the developing fetus and newborn. Here we studied whether supplemented perinatal polyunsaturated fatty acids (PUFAs) influence energy balance and fuel homeostasis later in life. Between day 10 after conception and day 10 after delivery, female rats were subjected to chow enriched with 10% fish-oil (FO-rich). Fish oil contains high concentrations of n-3 biosynthesis endpoint products, which may have caused the increased membrane phospholipid incorporation (particularly derived from the long-chain 20+:n-3 PUFAs) in 10-day old pup brains. Adult male offspring of FO-rich fed rats had reduced body weight (20%) at 3 months, and had lower levels of plasma leptin (54%), insulin (41%), triglycerides (65%), and lactate (46%) than controls. All differences between groups were lost 48h after streptozotocin (STZ) treatment. At 4.5 months of age, body weights of FO-rich were still lower (6%) than controls, but were associated with increased food intake, and increased insulin sensitivity (following intraperitoneal injection) to lower blood glucose levels relative to controls. We concluded that perinatal FO supplementation has lasting effects on body weight homeostasis and fuel metabolism in male offspring, but does not offer resistance against STZ-induced diabetes.

Original languageEnglish
Pages (from-to)938-943
Number of pages6
JournalHormone and Metabolic Research
Volume43
Issue number13
DOIs
Publication statusPublished - 2011

Fingerprint

Experimental Diabetes Mellitus
Streptozocin
Medical problems
Rats
Homeostasis
Fatty Acids
Fish Oils
Body Weight
Insulin
Biosynthesis
Omega-3 Fatty Acids
Leptin
Energy balance
Intraperitoneal Injections
Unsaturated Fatty Acids
Metabolism
Insulin Resistance
Blood Glucose
Lactic Acid
Brain

Keywords

  • adiponectin
  • docosahexaenoic acid
  • fetal programming
  • insulin
  • leptin

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Perinatal polyunstaurated fatty acids supplementation causes alterations in fuel homeostasis in adult male rats but does not offer resistance against STZ-induced diabetes. / Van Dijk, G.; Kacsndi, A.; Kbor-Nyakas, D. E.; Hgyes, E.; Nyakas, C.

In: Hormone and Metabolic Research, Vol. 43, No. 13, 2011, p. 938-943.

Research output: Contribution to journalArticle

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