Perinatal and intrafamily transmission of hepatitis B virus in three generations of a low-prevalence population

Katalin Ördög, Andrea Szendrôi, Katalin Szarka, Zoltán Kugler, Márta Csire, Beatrix Kapusinszky, Jiuru Xie, Katalin Csizmadia, Judit Brojnás, Erzsébet Rusvai, Ágnes Tempfli, G. Berencsi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Family members of 47 hepatitis B virus (HBV)-carrier pregnant women were tested for the presence of hepatitis B surface antigen (HBsAg), other markers of HBV infection, and hepatitis A virus (HAV) antibodies. Eleven members of six families were found to be HBV DNA positive. Five of the anti-HBe-positive persons were found to be HBV DNA carriers, too. The mean age of the HBV DNA carriers was found to be lower than that of Hbe carriers; therefore, it is suggested that seroconversion to HBe occurs before the resolution of HBV DNA carrier state. Superinfection with hepatitis A virus was not found to influence the elimination of HBV-carrier state, as there was no correlation found between the hepatitis A exposure and the hepatitis B virus markers in the families. The low HBV prevalence in the population (0.3%) was in contrast to the high prevalence of the families of the HBV-carrier mothers (27.1%) and family members with HBV markers (50.4%). Significant positive correlation was found in the proportion of HBV-positive children, and the HBV history of their parents. When fathers were shown to be seronegative, the probability of HBV transmission was reduced by a factor of 6 (12.5% instead of 75%) probably due to reduced viral load and possibly by other factors. Several results indicate, that the noncytocidal hepatitis B virus clearing mechanism suggested by Guidotti et al. [1996, 1999] was effective also in the HBV-carrier human population.

Original languageEnglish
Pages (from-to)194-204
Number of pages11
JournalJournal of Medical Virology
Volume70
Issue number2
DOIs
Publication statusPublished - Jun 1 2003

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Hepatitis B virus
Population
Carrier State
DNA
Hepatitis A Antibodies
Hepatitis A virus
Superinfection
Hepatitis A
Virus Diseases
Hepatitis B Surface Antigens
Viral Load
Fathers
Pregnant Women

Keywords

  • Elimination of HBV-carrier state
  • HBV-carrier pregnant women
  • Transmission before the preventive immunization

ASJC Scopus subject areas

  • Virology

Cite this

Perinatal and intrafamily transmission of hepatitis B virus in three generations of a low-prevalence population. / Ördög, Katalin; Szendrôi, Andrea; Szarka, Katalin; Kugler, Zoltán; Csire, Márta; Kapusinszky, Beatrix; Xie, Jiuru; Csizmadia, Katalin; Brojnás, Judit; Rusvai, Erzsébet; Tempfli, Ágnes; Berencsi, G.

In: Journal of Medical Virology, Vol. 70, No. 2, 01.06.2003, p. 194-204.

Research output: Contribution to journalArticle

Ördög, K, Szendrôi, A, Szarka, K, Kugler, Z, Csire, M, Kapusinszky, B, Xie, J, Csizmadia, K, Brojnás, J, Rusvai, E, Tempfli, Á & Berencsi, G 2003, 'Perinatal and intrafamily transmission of hepatitis B virus in three generations of a low-prevalence population', Journal of Medical Virology, vol. 70, no. 2, pp. 194-204. https://doi.org/10.1002/jmv.10378
Ördög, Katalin ; Szendrôi, Andrea ; Szarka, Katalin ; Kugler, Zoltán ; Csire, Márta ; Kapusinszky, Beatrix ; Xie, Jiuru ; Csizmadia, Katalin ; Brojnás, Judit ; Rusvai, Erzsébet ; Tempfli, Ágnes ; Berencsi, G. / Perinatal and intrafamily transmission of hepatitis B virus in three generations of a low-prevalence population. In: Journal of Medical Virology. 2003 ; Vol. 70, No. 2. pp. 194-204.
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AU - Csire, Márta

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