Perinatal alcohol exposure enhances nocistatin levels in adulthood

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Abstract

In earlier experiments perinatal hormonal imprinting by alcohol decreased the hormone content of immune cells for life. In the present study, both a single day (15% on the third postnatal day) and a long-term treatment schedule of alcohol exposure (3% for 21 days) of dams during lactation significantly (P < 0.01) enhanced endogenous levels of nocistatin in the blood plasma as well as in the cerebrospinal fluid of the offspring, measured in 3-month-old rats. Our data suggest that alcohol consumption during lactation can cause a life-long influence on nocistatin levels in the offspring and most likely modify nocistatin-related functions such as pain tolerance.

Original languageEnglish
Pages (from-to)173-175
Number of pages3
JournalAddiction Biology
Volume12
Issue number2
DOIs
Publication statusPublished - Jun 1 2007

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Keywords

  • Alcohol
  • Hormonal imprinting
  • Nocistatin
  • Opioids
  • Pain
  • Rat

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology
  • Psychiatry and Mental health

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