Perinatal alcohol exposure enhances nocistatin levels in adulthood

K. Tekes, M. Hantos, Melinda Gyenge, G. Csaba

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In earlier experiments perinatal hormonal imprinting by alcohol decreased the hormone content of immune cells for life. In the present study, both a single day (15% on the third postnatal day) and a long-term treatment schedule of alcohol exposure (3% for 21 days) of dams during lactation significantly (P <0.01) enhanced endogenous levels of nocistatin in the blood plasma as well as in the cerebrospinal fluid of the offspring, measured in 3-month-old rats. Our data suggest that alcohol consumption during lactation can cause a life-long influence on nocistatin levels in the offspring and most likely modify nocistatin-related functions such as pain tolerance.

Original languageEnglish
Pages (from-to)173-175
Number of pages3
JournalAddiction Biology
Volume12
Issue number2
DOIs
Publication statusPublished - Jun 2007

Fingerprint

Alcohols
Lactation
Alcohol Drinking
Cerebrospinal Fluid
Appointments and Schedules
Hormones
Pain
nocistatin
Therapeutics
Imprinting (Psychology)

Keywords

  • Alcohol
  • Hormonal imprinting
  • Nocistatin
  • Opioids
  • Pain
  • Rat

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Perinatal alcohol exposure enhances nocistatin levels in adulthood. / Tekes, K.; Hantos, M.; Gyenge, Melinda; Csaba, G.

In: Addiction Biology, Vol. 12, No. 2, 06.2007, p. 173-175.

Research output: Contribution to journalArticle

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