Periconceptional multivitamin supplementation and multimalformed offspring

E. Czeizel, Erika Medveczky

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

OBJECTIVE: To study the human teratogenic risk of a folic acid-containing multivitamin. METHODS: We evaluated the data set of two Hungarian intervention studies: a randomized double-blind, controlled trial and a two-cohort, controlled study of the same folic acid-containing multivitamin in participants of the Hungarian periconceptional service. RESULTS: Of 2471 supplemented and 2391 unsupplemented women, 18 and 21, respectively, had multiple congenital abnormalities in the randomized, controlled trial. Of 3056 supplemented and unsupplemented pairs in the two-cohort, controlled study, 33 and 32, respectively, were affected with multiple congenital abnormalities. After the combination of two data sets, the number of cases with multiple congenital abnormalities was 51 in the supplemented group and 53 in the unsupplemented group (odds ratio 0.89; 95% confidence interval 0.45, 1.68). In addition, there was no difference in the occurrence of specified multiple congenital abnormality entities or of unidentified multimalformed informative offspring. CONCLUSION: We found no evidence that periconceptional folic acid-containing multivitamin supplementation either prevents or induces multiple congenital abnormalities.

Original languageEnglish
Pages (from-to)1255-1261
Number of pages7
JournalObstetrics and Gynecology
Volume102
Issue number6
DOIs
Publication statusPublished - Dec 2003

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Multiple Abnormalities
Folic Acid
Cohort Studies
Randomized Controlled Trials
Odds Ratio
Confidence Intervals

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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Periconceptional multivitamin supplementation and multimalformed offspring. / Czeizel, E.; Medveczky, Erika.

In: Obstetrics and Gynecology, Vol. 102, No. 6, 12.2003, p. 1255-1261.

Research output: Contribution to journalArticle

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abstract = "OBJECTIVE: To study the human teratogenic risk of a folic acid-containing multivitamin. METHODS: We evaluated the data set of two Hungarian intervention studies: a randomized double-blind, controlled trial and a two-cohort, controlled study of the same folic acid-containing multivitamin in participants of the Hungarian periconceptional service. RESULTS: Of 2471 supplemented and 2391 unsupplemented women, 18 and 21, respectively, had multiple congenital abnormalities in the randomized, controlled trial. Of 3056 supplemented and unsupplemented pairs in the two-cohort, controlled study, 33 and 32, respectively, were affected with multiple congenital abnormalities. After the combination of two data sets, the number of cases with multiple congenital abnormalities was 51 in the supplemented group and 53 in the unsupplemented group (odds ratio 0.89; 95{\%} confidence interval 0.45, 1.68). In addition, there was no difference in the occurrence of specified multiple congenital abnormality entities or of unidentified multimalformed informative offspring. CONCLUSION: We found no evidence that periconceptional folic acid-containing multivitamin supplementation either prevents or induces multiple congenital abnormalities.",
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AB - OBJECTIVE: To study the human teratogenic risk of a folic acid-containing multivitamin. METHODS: We evaluated the data set of two Hungarian intervention studies: a randomized double-blind, controlled trial and a two-cohort, controlled study of the same folic acid-containing multivitamin in participants of the Hungarian periconceptional service. RESULTS: Of 2471 supplemented and 2391 unsupplemented women, 18 and 21, respectively, had multiple congenital abnormalities in the randomized, controlled trial. Of 3056 supplemented and unsupplemented pairs in the two-cohort, controlled study, 33 and 32, respectively, were affected with multiple congenital abnormalities. After the combination of two data sets, the number of cases with multiple congenital abnormalities was 51 in the supplemented group and 53 in the unsupplemented group (odds ratio 0.89; 95% confidence interval 0.45, 1.68). In addition, there was no difference in the occurrence of specified multiple congenital abnormality entities or of unidentified multimalformed informative offspring. CONCLUSION: We found no evidence that periconceptional folic acid-containing multivitamin supplementation either prevents or induces multiple congenital abnormalities.

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