Performance characterization of micromachined particle separation system based on Zweifach-Fung effect

Zoltán Fekete, Péter Nagy, Gergely Huszka, Ferenc Tolner, Anita Pongrácz, Péter Fürjes

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Integration of separation has always been a challenge in a microfluidic system. Human blood tests in clinical diagnostics often require cell-free samples in order to provide adequate sensitivity of measurements. This article characterizes the performance of microfluidic test structures utilizing the Zweifach-Fung effect in terms of two performance metrics: separation and purity efficiency. A series of silicon-glass based microfluidic chip were designed and fabricated by conventional MEMS technology. The influence of geometric parameters of several bifurcation arrangements was quantitatively analyzed under different flow conditions. Finite element modeling of the fluid flow in the vicinity of the bifurcations is also implemented to help the understanding of the experimental results. Our work contributes to optimal geometric design of separation components of microfluidic based diagnostic chips.

Original languageEnglish
Pages (from-to)89-94
Number of pages6
JournalSensors and Actuators, B: Chemical
Volume162
Issue number1
DOIs
Publication statusPublished - Feb 20 2012

Keywords

  • Bifurcation law
  • MEMS
  • Particle separation
  • Silicon microfluidics
  • Zweifach-Fung effect

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

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