Percutaneous translaminal angioplasty increases thromboxane A2 production in claudicants

P. Rossi, P. Kuukasjärvi, J. P. Salenius, M. Tarkka, T. Kerttula, J. Alanko, I. Muchá, A. Riutta

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Percutaneous transluminal angioplasty is an acute, local stimulus to platelets which activation is regarded as an important factor for a later restenosis. The balance between the production of prostacyclin and thromboxane A2 is of (patho)physiological importance due to their opposite actions on vascular tone and platelet reactivity. in this study we investigated the influence of percutaneous transluminal angioplasty of the peripheral arteries on prostacyclin and thromboxane A2 productions in vivo by measuring the excretions of their urinary index metabolites, 2,3-dinor-6-ketoprostaglandin F(1α) and 11-dehydrothromboxane B2 respectively, in 10 patients, We found a twofold increase in thromboxane A2, but no significant change in prostacyclin, production after peripheral transluminal angioplasty which shifted prostacyclin/thromboxane A2 balance to the direction of thromboxane A2 formation. This gives theoretical support to the use of thromboxane A2 synthase inhibitors and receptor antagonists as well as prostacyclin analogues in combination with peripheral percutaneous transluminal angioplasty to prevent thrombosis and restenosis.

Original languageEnglish
Pages (from-to)369-372
Number of pages4
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume56
Issue number5
Publication statusPublished - May 1997

Fingerprint

Thromboxane A2
Angioplasty
Epoprostenol
Platelets
Platelet Activation
Metabolites
Blood Vessels
Thrombosis
Blood Platelets
Arteries
Chemical activation

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Rossi, P., Kuukasjärvi, P., Salenius, J. P., Tarkka, M., Kerttula, T., Alanko, J., ... Riutta, A. (1997). Percutaneous translaminal angioplasty increases thromboxane A2 production in claudicants. Prostaglandins Leukotrienes and Essential Fatty Acids, 56(5), 369-372.

Percutaneous translaminal angioplasty increases thromboxane A2 production in claudicants. / Rossi, P.; Kuukasjärvi, P.; Salenius, J. P.; Tarkka, M.; Kerttula, T.; Alanko, J.; Muchá, I.; Riutta, A.

In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 56, No. 5, 05.1997, p. 369-372.

Research output: Contribution to journalArticle

Rossi, P, Kuukasjärvi, P, Salenius, JP, Tarkka, M, Kerttula, T, Alanko, J, Muchá, I & Riutta, A 1997, 'Percutaneous translaminal angioplasty increases thromboxane A2 production in claudicants', Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 56, no. 5, pp. 369-372.
Rossi P, Kuukasjärvi P, Salenius JP, Tarkka M, Kerttula T, Alanko J et al. Percutaneous translaminal angioplasty increases thromboxane A2 production in claudicants. Prostaglandins Leukotrienes and Essential Fatty Acids. 1997 May;56(5):369-372.
Rossi, P. ; Kuukasjärvi, P. ; Salenius, J. P. ; Tarkka, M. ; Kerttula, T. ; Alanko, J. ; Muchá, I. ; Riutta, A. / Percutaneous translaminal angioplasty increases thromboxane A2 production in claudicants. In: Prostaglandins Leukotrienes and Essential Fatty Acids. 1997 ; Vol. 56, No. 5. pp. 369-372.
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