Peptides containing β-amino acid patterns

Challenges and successes in medicinal chemistry

Chiara Cabrele, T. Martinek, Oliver Reiser, Łukasz Berlicki

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

The construction of bioactive peptides using β-amino acid-containing sequence patterns is a very promising strategy to obtain analogues that exhibit properties of high interest for medicinal chemistry applications. β-Amino acids have been shown to modulate the conformation, dynamics, and proteolytic susceptibility of native peptides. They can be either combined with α-amino acids by following specific patterns, which results in backbone architectures with well-defined orientations of the side chain functional groups, or assembled in de novo-designed bioactive β- or α,β-peptidic sequences. Such peptides display various biological functions, including antimicrobial activity, inhibition of protein-protein interactions, agonism/antagonism of GPCR ligands, and anti-angiogenic activity.

Original languageEnglish
Pages (from-to)9718-9739
Number of pages22
JournalJournal of Medicinal Chemistry
Volume57
Issue number23
DOIs
Publication statusPublished - Dec 11 2014

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Pharmaceutical Chemistry
Amino Acids
Peptides
Amino Acid Sequence
Proteins
Ligands

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Medicine(all)

Cite this

Peptides containing β-amino acid patterns : Challenges and successes in medicinal chemistry. / Cabrele, Chiara; Martinek, T.; Reiser, Oliver; Berlicki, Łukasz.

In: Journal of Medicinal Chemistry, Vol. 57, No. 23, 11.12.2014, p. 9718-9739.

Research output: Contribution to journalArticle

Cabrele, Chiara ; Martinek, T. ; Reiser, Oliver ; Berlicki, Łukasz. / Peptides containing β-amino acid patterns : Challenges and successes in medicinal chemistry. In: Journal of Medicinal Chemistry. 2014 ; Vol. 57, No. 23. pp. 9718-9739.
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