Peptides as complexing agents: Factors influencing the structure and thermodynamic stability of peptide complexes

Research output: Contribution to journalReview article

110 Citations (Scopus)

Abstract

Peptides are versatile and powerful ligands to form stable complexes with the great majority of metal ions. The outstanding stability of peptide complexes is, however, linked to the involvement of terminal amino and subsequent deprotonated amide nitrogen atoms of the peptide backbone in metal binding. Copper(II), nickel(II) and palladium(II) ions are the most common examples for the formation of these complexes. Any side chain can influence the coordination chemistry of peptides but histidyl and cysteinyl residues are the most effective to enhance the stability and to change the structure of peptide complexes significantly.

Original languageEnglish
Pages (from-to)2225-2233
Number of pages9
JournalCoordination Chemistry Reviews
Volume256
Issue number19-20
DOIs
Publication statusPublished - Oct 1 2012

Keywords

  • Amino acids
  • Coordination chemistry
  • Peptides
  • Transition metals

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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