Peptidergic innervation of human cerebral blood vessels and saccular aneurysms

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Peptidergic innervation of the human cerebral vasculature has not yet been described in detail and its role in the maintenance of cerebral autoregulation still needs to be established. Similarly, few data exist on the innervation of vascular malformations. The aim of this study was to clarify the peptidergic innervation patterns of human cerebral arteries of various sizes, and, for the first time, that of saccular aneurysms. Light microscopic study of whole-mount preparations of human cerebral arteries and aneurysm sacs resected either during tumor removal or after neck-clipping were carried out by means of silver-intensified light microscopic immunocytochemistry visualizing neuropeptide-Y calcitonin gene-related peptide and substance P immunoreactivity. Systematic morphological investigations confirmed the presence of longitudinal fiber bundles on the adventitia and a network-like deeper peptidergic system at the adventitia-media border, while in smaller pial and intraparenchymal vessles, only sparse longitudinal immunopositive axons could be detected. The innervation pattern was totally absent in the wall of saccular aneurysms with the complete disappearance of peptidergic nerve fibers in some areas. To the best of our knowledge neither the disappearance of this network on small pial and intraparenchymal vessels, nor the absence of an innervation pattern in saccular aneurysms have been described before. Nonhomogeneous peptidergic innervation of the human cerebral vascular tree might be one of the factors responsible for the distinct autoregulatory properties of the capacitance and resistance vessels. Malfunction of this vasoregulatory system might lead to the impairment of autoregulation during pathological conditions such as subarachnoid hemorrhage.

Original languageEnglish
Pages (from-to)383-388
Number of pages6
JournalActa Neuropathologica
Volume98
Issue number4
DOIs
Publication statusPublished - Oct 1999

Fingerprint

Aneurysm
Blood Vessels
Adventitia
Cerebral Arteries
Homeostasis
Light
Vascular Malformations
Calcitonin Gene-Related Peptide
Neuropeptide Y
Intracranial Aneurysm
Subarachnoid Hemorrhage
Substance P
Nerve Fibers
Silver
Axons
Neck
Immunohistochemistry
Maintenance
Neoplasms

Keywords

  • Autoregulation
  • Cerebral aneurysm
  • Neuropeptides

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Peptidergic innervation of human cerebral blood vessels and saccular aneurysms. / Büki, A.; Horváth, Zoltán; Kalló, I.; Liposits, Z.; Lengvári, I.; Dóczi, T.

In: Acta Neuropathologica, Vol. 98, No. 4, 10.1999, p. 383-388.

Research output: Contribution to journalArticle

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