Peptide presentation by HLA-DQ molecules is associated with the development of immune tolerance

Máté Manczinger, Lajos Kemény

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

HLA class II proteins are important elements of human adaptive immune recognition and are associated with numerous infectious and immune-mediated diseases. These highly variable molecules can be classified into DP, DQ and DR groups. It has been proposed that in contrast withDPand DR, epitope binding byDQvariants rather results in immune tolerance. However, the pieces of evidence are limited and controversial. We found that DQ molecules bind more human epitopes than DR. Pathogen-associated epitopes bound by DQ molecules are more similar to human proteins than the ones bound by DR. Accordingly, DQ molecules bind epitopes of significantly different pathogen species. Moreover, the binding of autoimmunity-associated epitopes by DQ confers protection from autoimmune diseases. Our results suggest a special role of HLA-DQ in immune homeostasis and help to better understand the association of HLA molecules with infectious and autoimmune diseases.

Original languageEnglish
Article numbere5118
JournalPeerJ
Volume2018
Issue number7
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

HLA-DQ Antigens
Immune Tolerance
immunosuppression
epitopes
Epitopes
peptides
Peptides
Molecules
autoimmune diseases
Pathogens
Autoimmune Diseases
autoimmunity
pathogens
Immune System Diseases
Autoimmunity
infectious diseases
Communicable Diseases
homeostasis
Proteins
Homeostasis

Keywords

  • Antigen presentation
  • Autoimmunity
  • Central tolerance
  • Epitopes
  • HLA-DQ
  • Host-pathogen interaction
  • Immune defense
  • Immune recognition
  • Immune tolerance
  • Type 1 diabetes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Peptide presentation by HLA-DQ molecules is associated with the development of immune tolerance. / Manczinger, Máté; Kemény, Lajos.

In: PeerJ, Vol. 2018, No. 7, e5118, 01.01.2018.

Research output: Contribution to journalArticle

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