Peptide Models. 3. Conformational Potential Energy Hypersurface of Formyl-l-valinamide

Wladia Viviani, Jean Louis Rivail, Imre G. Csizmadia, Andras Perczel

Research output: Contribution to journalArticle

81 Citations (Scopus)


Out of the 27 legitimate minima of the 3D Ramachandran map, E = E(ɸ,ψ,χ1), the existing 20 conformations of formyl-L-valinamide have been determined by ab-initio SCF-MO computations. In the gauche side-chain conformations (χ1 = 60° and χ1 = 300°), the pattern of minima on the backbone potential energy surface, i.e. on the 2D Ramachandran map, E = E(ɸ,ψ), is equivalent to the backbone conformation of the corresponding L-alanine derivative, which shows the absence of the αL and ϵL conformations. However, in the anti conformation (χ1 = 180°) an additional backbone conformation, the one labeled as δL, has disappeared. This implied that, at the χ1 = 180° torsional angle, on the E = E(χ1) potential curve crosssection, the δL conformation is destabilized to such a degree that the δL minimum is replaced by a higher indexed critical point (λ = 1) on the potential energy hypersurface of 3N-6 independent variables. The βL backbone conformation is also destabilized at χ1 = 180° to a higher energy than either of the two nonequivalent gauche conformations; nevertheless, it remained a minimum. In contrast to the above, three backbone conformations (γL, γD, and αD) are stabilized in the anti (χ1 = 180°) side-chain conformation with respect to the two nonequivalent gauche conformations. A new method has been developed for a unique energy partitioning in order to quantify the magnitude of the side chain/backbone interaction. The numerical values for such side chain/backbone interactions have been calculated for the iPr group in the various backbone conformations of formyl-L-valinamide relative to that of hydrogen in the corresponding backbone conformations of formylglycinamide. The computations have clearly shown that even an apolar side chain was able to interact with the peptide backbone so drastically that it could annihilate one of the otherwise legitimate minima through an unfavorable backbone and side-chain torsional angles combination.

Original languageEnglish
Pages (from-to)8321-8329
Number of pages9
JournalJournal of the American Chemical Society
Issue number18
Publication statusPublished - Sep 1 1993

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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