Peptide and protein based pharmaceuticals

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Citations (Scopus)

Abstract

It is predicted that in the 21st century there will be more and more new drug investments that violates the Lipinski's "rule-of-five". Among them, peptides have received increased interest in the current drug therapies. Advantages of peptide-based pharmaceuticals are the high potency and selectivity as well as their low accumulation in tissues; thus, they have potentially lower toxicity than the small drug molecules. Furthermore, the high chemical and biological diversity of peptides provide a broad range of targets, which could represent a basis for personalized medication. Currently, there are more than 70 approved peptide drugs on the market, generating an annual sale close to USD 20 billion in 2012. About half of them are presented in this chapter, which ones are used for the treatment of diabetes, cancers, multiple sclerosis, HIV, hereditary angioedema, respiratory distress syndrome, prevention of thrombosis or relief pain. Next to the structures of the peptide-based pharmaceuticals, their biological activity on the mentioned diseases will be shortly discussed. An outlook for the new peptide-based drug development indicates high perspectives of this area.

Original languageEnglish
Title of host publicationAmino Acids, Peptides and Proteins, Volume 38
EditorsEtelka Farkas, Maxim Ryadnov
PublisherRoyal Society of Chemistry
Pages203-252
Number of pages50
ISBN (Print)9781849735858
DOIs
Publication statusPublished - Jan 1 2014

Publication series

NameAmino Acids, Peptides and Proteins
Volume38
ISSN (Print)1361-5904

ASJC Scopus subject areas

  • Biochemistry

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  • Cite this

    Mező, G. (2014). Peptide and protein based pharmaceuticals. In E. Farkas, & M. Ryadnov (Eds.), Amino Acids, Peptides and Proteins, Volume 38 (pp. 203-252). (Amino Acids, Peptides and Proteins; Vol. 38). Royal Society of Chemistry. https://doi.org/10.1039/9781849737081-00203