Peptic ulcer disease with related drug treatment in pregnant women and congenital abnormalities in their offspring

F. Bánhidy, Abdallah Dakhlaoui, E. Puhó, E. Czeizel

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Peptic ulcer disease (PUD) is a common disease which can also occur in pregnant women. However, the possible association of PUD and related drug treatments in pregnant women with the risk of structural birth defects (i.e. congenital abnormalities [CA]) in their offspring has not been estimated in controlled population-based epidemiological studies. Thus, the prevalence of PUD in pregnant women who later delivered babies (cases) with different CA and in pregnant women who delivered newborns without CA (controls) was compared in the Hungarian Case-Control Surveillance of Congenital Abnormalities. Controls were matched to cases. Of 22843 cases with congenital abnormalities, 182 (0.80%) had mothers with reported/recorded PUD, while of 38151 controls, 261 (0.68%) were born to mothers with reported/recorded PUD. However, PUD(?) based on maternal information and/or unspecified diagnostic criteria, and PUD(!) based on endoscopic diagnosis showed different variables of mothers and newborn infants. Thus, finally, 20 case mothers and 58 control mothers with PUD(!) and related drugs were evaluated in detail. There was no higher risk for total CA group in the offspring of mothers with PUD during pregnancy (adjusted OR with 95% CI: 0.6, 0.3-0.9). Specific CA groups in cases were also assessed versus controls, but specified CA had no higher risk in the offspring of pregnant women with PUD and related drug treatments. In conclusion, a higher rate of CA was not found in the offspring of mothers with PUD.

Original languageEnglish
Pages (from-to)26-33
Number of pages8
JournalCongenital Anomalies
Volume51
Issue number1
DOIs
Publication statusPublished - Mar 2011

Fingerprint

Peptic Ulcer
Pregnant Women
Mothers
Pharmaceutical Preparations
Therapeutics
Newborn Infant
Epidemiologic Studies
Pregnancy

Keywords

  • Congenital abnormality
  • Peptic ulcer disease
  • Population-based case-control study
  • Related drug treatment

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health
  • Embryology

Cite this

Peptic ulcer disease with related drug treatment in pregnant women and congenital abnormalities in their offspring. / Bánhidy, F.; Dakhlaoui, Abdallah; Puhó, E.; Czeizel, E.

In: Congenital Anomalies, Vol. 51, No. 1, 03.2011, p. 26-33.

Research output: Contribution to journalArticle

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