Peptic esophageal stricture: Medical treatment

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Peptic esophageal stricture as a consequence of gastroesophageal reflux disease is the most frequent among benign esophageal strictures. The incidence is low and has been decreasing since the 1990s with a parallel increase in proton pump inhibitor use. Dysphagia is a common symptom: accurate diagnostic procedures (barium esophagogram, upper endoscopy with biopsies) have to be performed to exclude malignant causes first. Medical (acid-suppressive) therapy, endoscopic dilation and surgical intervention are the main therapeutic options. Based on the results of randomized and observational studies evaluating the effect of acid-suppressive therapy on peptic stricture outcome, healing the coexistent esophagitis seems to be essential. Effective acid-suppressive therapy with proton pump inhibitors may reduce the need for repeated dilations and provide symptom relief and better clinical outcome. In refractory strictures, local steroid injection is likely beneficial.

Original languageEnglish
Pages (from-to)31-37
Number of pages7
JournalDigestive Diseases
Volume27
Issue number1
DOIs
Publication statusPublished - May 2009

Fingerprint

Esophageal Stenosis
Digestion
Proton Pump Inhibitors
Acids
Dilatation
Pathologic Constriction
Esophagitis
Barium
Therapeutics
Deglutition Disorders
Gastroesophageal Reflux
Endoscopy
Observational Studies
Steroids
Biopsy
Injections
Incidence

Keywords

  • Benign peptic stricture
  • Esophagitis
  • Gastroesophageal reflux disease
  • Proton pump inhibitor

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Peptic esophageal stricture : Medical treatment. / Pregun, István; Hritz, I.; Tulassay, Z.; Herszényi, L.

In: Digestive Diseases, Vol. 27, No. 1, 05.2009, p. 31-37.

Research output: Contribution to journalArticle

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