Peptaibols and related peptaibiotics of Trichoderma

A review

A. Szekeres, B. Leitgeb, L. Kredics, Zsuzsanna Antal, L. Hatvani, L. Manczinger, C. Vágvölgyi

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Peptaibols and the related peptaibiotics are linear, amphipathic polypeptides. More than 300 of these secondary metabolites have been described to date. These compounds are composed of 5-20 amino acids and are generally produced in microheterogeneous mixtures. Peptaibols and peptaibiotics with unusual amino acid content are the result of non-ribosomal biosynthesis. Large multifunctional enzymes known as peptide synthetases assemble these molecules by the multiple carrier thiotemplate mechanism from a remarkable range of precursors, which can be N-methylated, acylated or reduced. Peptaibols and peptaibiotics show interesting physico-chemical and biological properties including the formation of pores in bilayer lipid membranes, as well as antibacterial, antifungal, occasionally antiviral activities, and may elicit plant resistance. The three-dimensional structure of peptaibols and peptaibiotics is characterized predominantly by one type of the helical motifs α-helix, 310-helix and β-bend ribbon spiral. The aim of this review is to summarize the data available about the biosynthesis, biological activity and conformational properties of peptaibols and peptaibiotics described from Trichoderma species.

Original languageEnglish
Pages (from-to)137-168
Number of pages32
JournalActa Microbiologica et Immunologica Hungarica
Volume52
Issue number2
DOIs
Publication statusPublished - 2005

Fingerprint

Peptaibols
Trichoderma
Multifunctional Enzymes
Peptide Synthases
Amino Acids
Lipid Bilayers
Membrane Lipids
Antiviral Agents
Peptides

Keywords

  • β-bend ribbon spiral
  • Alamethicin
  • Antimicrobial activity
  • Helical structures
  • Lipopeptaibols
  • Non-ribosomal biosynthesis
  • Peptaibiotics
  • Peptaibols
  • Pro-kinked α-helix
  • Trichoderma

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Medicine(all)
  • Microbiology

Cite this

Peptaibols and related peptaibiotics of Trichoderma : A review. / Szekeres, A.; Leitgeb, B.; Kredics, L.; Antal, Zsuzsanna; Hatvani, L.; Manczinger, L.; Vágvölgyi, C.

In: Acta Microbiologica et Immunologica Hungarica, Vol. 52, No. 2, 2005, p. 137-168.

Research output: Contribution to journalArticle

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