Pelvic vascular prospects for uterine transplantation

Krishen Sieunarine, Deborah C.M. Boyle, David J. Corless, David E. Noakes, Laszlo Ungar, Celia E. Marr, Ian Lindsay, Giuseppe Del Priore, J. Richard Smith

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

While developing the technique of abdominal radical trachelectomy for conservative cervical cancer management, the vascular supply of the uterus was thoroughly examined. This was a prelude to study the possibility of uterine transplantation where initial concerns were about how uterine artery anastomosis might be achieved and the subsequent function of these vessels in pregnancy. In experiment 1, the uterine arteries in two sows were divided and reanastomosed. At 6 weeks, all sows including control were inseminated. After weaning 3 months after delivery, the sows were killed, and postmortem studies were undertaken. Successful reanastomoses of the uterine arteries were accomplished in both study sows. After insemination, pregnancy proceeded uneventfully, and both sows farrowed normally with average litter sizes. Histopathology of the uterine arteries revealed minimal intimal fibrosis across all anastomotic sites. Uterine artery anastomosis in the porcine model is feasible with subsequent normal vascular function in pregnancy of the anastomosed vessels.

Original languageEnglish
Pages (from-to)217-222
Number of pages6
JournalInternational Surgery
Volume91
Issue number4
Publication statusPublished - 2006

Keywords

  • Pelvic vasculature
  • Uterine artery reanastomosis
  • Uterine transplantation

ASJC Scopus subject areas

  • Surgery

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    Sieunarine, K., Boyle, D. C. M., Corless, D. J., Noakes, D. E., Ungar, L., Marr, C. E., Lindsay, I., Del Priore, G., & Smith, J. R. (2006). Pelvic vascular prospects for uterine transplantation. International Surgery, 91(4), 217-222.