Pelvic plexus contributes ganglion cells to the hindgut enteric nervous system

N. Nagy, Katherine C. Brewer, Olive Mwizerwa, Allan M. Goldstein

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The hindgut enteric nervous system (ENS) contains cells originating from vagal and sacral neural crest. In avians, the sacral crest gives rise to the nerve of Remak (NoR) and pelvic plexus. Whereas the NoR has been suggested to serve as the source of sacral crest-derived cells to the gut, the contribution of the pelvic ganglia is unknown. The purpose of this study was to test the hypothesis that the pelvic ganglia contribute ganglion cells to the hindgut ENS. We observed that the quail pelvic plexus develops from neural crest-derived cells that aggregate around the cloaca at embryonic day 5. Using chick-quail tissue recombinations, we found that hindgut grafts did not contain enteric ganglia unless the pelvic plexus was included. Neurofibers extended from the NoR into the intestine, but no ganglion cell contribution from the NoR was identified. These results demonstrate that the pelvic plexus, and not the NoR, serves as the staging area for sacral crest-derived cells to enter the avian hindgut, confirming the evolutionary conservation of this important embryologic process.

Original languageEnglish
Pages (from-to)73-83
Number of pages11
JournalDevelopmental Dynamics
Volume236
Issue number1
DOIs
Publication statusPublished - Jan 2007

Fingerprint

Hypogastric Plexus
Enteric Nervous System
Ganglia
Quail
Neural Crest
Cloaca
Genetic Recombination
Intestines
Transplants
Neurons

Keywords

  • Enteric nervous system
  • Hirschsprung's disease
  • Nerve of Remak
  • Pelvic plexus
  • Sacral neural crest

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Pelvic plexus contributes ganglion cells to the hindgut enteric nervous system. / Nagy, N.; Brewer, Katherine C.; Mwizerwa, Olive; Goldstein, Allan M.

In: Developmental Dynamics, Vol. 236, No. 1, 01.2007, p. 73-83.

Research output: Contribution to journalArticle

Nagy, N. ; Brewer, Katherine C. ; Mwizerwa, Olive ; Goldstein, Allan M. / Pelvic plexus contributes ganglion cells to the hindgut enteric nervous system. In: Developmental Dynamics. 2007 ; Vol. 236, No. 1. pp. 73-83.
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