Pelletization of needle-shaped phenylbutazone crystals

Á Beretzky, P. Kása, K. Pintye-Hódi, J. Bajdik, P. Szabó-Révész, I. Erös

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The flowability of needle- or plate-shaped crystals is very poor and the direct compression of these crystals is difficult. Commercial phenylbutazone consists of needle crystals and it has three polymorphs. The aim of this work was to investigate the solid-state thermal stability of phenylbutazone at condition of the pelletization process (40°C; 60 min). The other aim was the preparation of phenylbutazone pellets with centrifugal granulator. Based non the flowability and the other parameters of, the pellets, they are suitable for capsule filling or tabletting. The centrifugal granulation and the conditions were favourable for the preparation of pellets from phenylbutazone in the form of needle crystals.

Original languageEnglish
Pages (from-to)529-539
Number of pages11
JournalJournal of Thermal Analysis and Calorimetry
Volume69
Issue number2
DOIs
Publication statusPublished - 2002

Fingerprint

Phenylbutazone
needles
Needles
pellets
Crystals
crystals
Granulators
preparation
Granulation
capsules
Polymorphism
Capsules
Compaction
Thermodynamic stability
thermal stability
solid state

Keywords

  • Centrifugal granulator
  • DSC
  • Pelletization
  • Phenylbutazone

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Pelletization of needle-shaped phenylbutazone crystals. / Beretzky, Á; Kása, P.; Pintye-Hódi, K.; Bajdik, J.; Szabó-Révész, P.; Erös, I.

In: Journal of Thermal Analysis and Calorimetry, Vol. 69, No. 2, 2002, p. 529-539.

Research output: Contribution to journalArticle

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AU - Erös, I.

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