Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease

Istvan Kapas, K. Majtényi, Klara Törö, E. Keller, Till Voigtländer, Gabor G. Kovacs

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In the present study we evaluated cases referred as suspected Creutzfeldt-Jakob disease (CJD). Five out of 59 without prion disease showed neuropathological features of pellagra encephalopathy with widespread chromatolytic neurons (age range 40-48 years at death; one woman). These patients presentedwith a progressive neuropsychiatric disorder lasting for 2 to 24 months. Common symptoms included gait disorder, para- or tetraspasticity, extrapyramidal symptoms, incontinence, and myoclonus. Protein 14-3-3 in the cerebrospinal fluid was examined in a single patient and was positive, allowing the clinical classification as probable sporadic CJD. Pellagra encephalopathy may be considered as a differential diagnosis of CJD including detection of protein 14-3-3.

Original languageEnglish
Pages (from-to)231-235
Number of pages5
JournalMetabolic Brain Disease
Volume27
Issue number2
DOIs
Publication statusPublished - Jun 2012

Fingerprint

Pellagra
14-3-3 Proteins
Creutzfeldt-Jakob Syndrome
Brain Diseases
Differential Diagnosis
Myoclonus
Prion Diseases
Gait
Cerebrospinal Fluid
Cerebrospinal fluid
Neurons
Prions

Keywords

  • Chromatolysis
  • Creutzfeldt-Jakob disease
  • Dementia
  • Pellagra
  • Prion
  • Surveillance

ASJC Scopus subject areas

  • Clinical Neurology
  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease. / Kapas, Istvan; Majtényi, K.; Törö, Klara; Keller, E.; Voigtländer, Till; Kovacs, Gabor G.

In: Metabolic Brain Disease, Vol. 27, No. 2, 06.2012, p. 231-235.

Research output: Contribution to journalArticle

Kapas, Istvan ; Majtényi, K. ; Törö, Klara ; Keller, E. ; Voigtländer, Till ; Kovacs, Gabor G. / Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease. In: Metabolic Brain Disease. 2012 ; Vol. 27, No. 2. pp. 231-235.
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