Patterning of embryonic blood vessels

Amanda C. LaRue, Vladimir A. Mironov, W. Scott Argraves, András Czirók, Paul A. Fleming, Christopher J. Drake

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Morphometric methods were developed to characterize the geometry of vascular patterns in avian and murine embryos. By using these methods, we found that networks of blood vessels formed during vasculogenesis share similar geometric properties (i.e., mean blood vessel diameters and avascular space diameters) regardless of developmental stage, location, or species in which they form. We also found that endothelial cell density within a unit area of an embryonic vasculature could be used to accurately distinguish between a small diameter, capillary-like vascular network (low endothelial cell density) and a large diameter, presinusoidal network (high endothelial cell density). Furthermore, we show that endothelial cell size remains constant in small and large diameter vessels, indicating that increased endothelial cell size is not the basis for diversity in vessel diameter. These observations serve as a foundation for future studies seeking to evaluate the effects of agents or genetic mutations on aspects of vasculogenesis.

Original languageEnglish
Pages (from-to)21-29
Number of pages9
JournalDevelopmental Dynamics
Volume228
Issue number1
DOIs
Publication statusPublished - Sep 1 2003

Keywords

  • Coronary
  • Endothelial cell
  • Morphogenesis
  • Vascular patterning
  • Vasculogenesis

ASJC Scopus subject areas

  • Developmental Biology

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  • Cite this

    LaRue, A. C., Mironov, V. A., Argraves, W. S., Czirók, A., Fleming, P. A., & Drake, C. J. (2003). Patterning of embryonic blood vessels. Developmental Dynamics, 228(1), 21-29. https://doi.org/10.1002/dvdy.10339