Pattern recognition receptors: A contemporary view on liver diseases

Gyongyi Szabo, Angela Dolganiuc, Pranoti Mandrekar

Research output: Contribution to journalShort survey

118 Citations (Scopus)

Abstract

Pattern recognition receptors (PRRs) function as sensors of microbial danger signals enabling the vertebrate host to initiate an immune response. PRRs are present not only in immune cells but also in liver parenchymal cells and the complexity of the cell populations provide unique aspects to pathogen recognition and tissue damage in the liver. This review discusses the role of different PRRs in pathogen recognition in the liver, and focuses on the role of PRRs in hepatic inflammation, cholestasis, ischemia, repair and fibrosis. PRRs as novel therapeutic targets are evaluated.

Original languageEnglish
Pages (from-to)287-298
Number of pages12
JournalHepatology
Volume44
Issue number2
DOIs
Publication statusPublished - Aug 2006

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Pattern Recognition Receptors
Liver Diseases
Liver
Cholestasis
Vertebrates
Fibrosis
Ischemia
Inflammation
Population

ASJC Scopus subject areas

  • Hepatology

Cite this

Pattern recognition receptors : A contemporary view on liver diseases. / Szabo, Gyongyi; Dolganiuc, Angela; Mandrekar, Pranoti.

In: Hepatology, Vol. 44, No. 2, 08.2006, p. 287-298.

Research output: Contribution to journalShort survey

Szabo, Gyongyi ; Dolganiuc, Angela ; Mandrekar, Pranoti. / Pattern recognition receptors : A contemporary view on liver diseases. In: Hepatology. 2006 ; Vol. 44, No. 2. pp. 287-298.
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