Pathophysiological dilemmas of lipedema

E. Szél, L. Kemény, G. Groma, G. Szolnoky

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Lipedema is a common, but often underdiagnosed masquerading disease of obesity, which almost exclusively affects females. There are many debates regarding the diagnosis as well as the treatment strategies of the disease. The clinical diagnosis is relatively simple, however, knowledge regarding the pathomechanism is less than limited and curative therapy does not exist at all demanding an urgent need for extensive research. According to our hypothesis, lipedema is an estrogen-regulated polygenetic disease, which manifests in parallel with feminine hormonal changes and leads to vasculo- and lymphangiopathy. Inflammation of the peripheral nerves and sympathetic innervation abnormalities of the subcutaneous adipose tissue also involving estrogen may be responsible for neuropathy. Adipocyte hyperproliferation is likely to be a secondary phenomenon maintaining a vicious cycle. Herein, the relevant articles are reviewed from 1913 until now and discussed in context of the most likely mechanisms leading to the disease, which could serve as a starting point for further research.

Original languageEnglish
Pages (from-to)599-606
Number of pages8
JournalMedical Hypotheses
Volume83
Issue number5
DOIs
Publication statusPublished - Nov 1 2014

Fingerprint

Estrogens
Subcutaneous Fat
Peripheral Nerves
Research
Adipocytes
Obesity
Inflammation
Lipedema
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pathophysiological dilemmas of lipedema. / Szél, E.; Kemény, L.; Groma, G.; Szolnoky, G.

In: Medical Hypotheses, Vol. 83, No. 5, 01.11.2014, p. 599-606.

Research output: Contribution to journalArticle

Szél, E, Kemény, L, Groma, G & Szolnoky, G 2014, 'Pathophysiological dilemmas of lipedema', Medical Hypotheses, vol. 83, no. 5, pp. 599-606. https://doi.org/10.1016/j.mehy.2014.08.011
Szél, E. ; Kemény, L. ; Groma, G. ; Szolnoky, G. / Pathophysiological dilemmas of lipedema. In: Medical Hypotheses. 2014 ; Vol. 83, No. 5. pp. 599-606.
@article{253990c8a6ef47ad9d161a1b22c022f8,
title = "Pathophysiological dilemmas of lipedema",
abstract = "Lipedema is a common, but often underdiagnosed masquerading disease of obesity, which almost exclusively affects females. There are many debates regarding the diagnosis as well as the treatment strategies of the disease. The clinical diagnosis is relatively simple, however, knowledge regarding the pathomechanism is less than limited and curative therapy does not exist at all demanding an urgent need for extensive research. According to our hypothesis, lipedema is an estrogen-regulated polygenetic disease, which manifests in parallel with feminine hormonal changes and leads to vasculo- and lymphangiopathy. Inflammation of the peripheral nerves and sympathetic innervation abnormalities of the subcutaneous adipose tissue also involving estrogen may be responsible for neuropathy. Adipocyte hyperproliferation is likely to be a secondary phenomenon maintaining a vicious cycle. Herein, the relevant articles are reviewed from 1913 until now and discussed in context of the most likely mechanisms leading to the disease, which could serve as a starting point for further research.",
author = "E. Sz{\'e}l and L. Kem{\'e}ny and G. Groma and G. Szolnoky",
year = "2014",
month = "11",
day = "1",
doi = "10.1016/j.mehy.2014.08.011",
language = "English",
volume = "83",
pages = "599--606",
journal = "Medical Hypotheses",
issn = "0306-9877",
publisher = "Churchill Livingstone",
number = "5",

}

TY - JOUR

T1 - Pathophysiological dilemmas of lipedema

AU - Szél, E.

AU - Kemény, L.

AU - Groma, G.

AU - Szolnoky, G.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Lipedema is a common, but often underdiagnosed masquerading disease of obesity, which almost exclusively affects females. There are many debates regarding the diagnosis as well as the treatment strategies of the disease. The clinical diagnosis is relatively simple, however, knowledge regarding the pathomechanism is less than limited and curative therapy does not exist at all demanding an urgent need for extensive research. According to our hypothesis, lipedema is an estrogen-regulated polygenetic disease, which manifests in parallel with feminine hormonal changes and leads to vasculo- and lymphangiopathy. Inflammation of the peripheral nerves and sympathetic innervation abnormalities of the subcutaneous adipose tissue also involving estrogen may be responsible for neuropathy. Adipocyte hyperproliferation is likely to be a secondary phenomenon maintaining a vicious cycle. Herein, the relevant articles are reviewed from 1913 until now and discussed in context of the most likely mechanisms leading to the disease, which could serve as a starting point for further research.

AB - Lipedema is a common, but often underdiagnosed masquerading disease of obesity, which almost exclusively affects females. There are many debates regarding the diagnosis as well as the treatment strategies of the disease. The clinical diagnosis is relatively simple, however, knowledge regarding the pathomechanism is less than limited and curative therapy does not exist at all demanding an urgent need for extensive research. According to our hypothesis, lipedema is an estrogen-regulated polygenetic disease, which manifests in parallel with feminine hormonal changes and leads to vasculo- and lymphangiopathy. Inflammation of the peripheral nerves and sympathetic innervation abnormalities of the subcutaneous adipose tissue also involving estrogen may be responsible for neuropathy. Adipocyte hyperproliferation is likely to be a secondary phenomenon maintaining a vicious cycle. Herein, the relevant articles are reviewed from 1913 until now and discussed in context of the most likely mechanisms leading to the disease, which could serve as a starting point for further research.

UR - http://www.scopus.com/inward/record.url?scp=84908259423&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908259423&partnerID=8YFLogxK

U2 - 10.1016/j.mehy.2014.08.011

DO - 10.1016/j.mehy.2014.08.011

M3 - Article

C2 - 25200646

AN - SCOPUS:84908259423

VL - 83

SP - 599

EP - 606

JO - Medical Hypotheses

JF - Medical Hypotheses

SN - 0306-9877

IS - 5

ER -