Pathophysiological and clinical approach to cirrhotic cardiomyopathy

Alida Páll, Árpád Czifra, Zsuzsanna Vitális, Mária Papp, György Paragh, Zoltán Szabó

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Hyperdynamic circulation, systolic and diastolic left ventricular dysfunction and certain electrophysiological abnormalities have been associated with cirrhosis and known for a long time. These clinical features have been introduced as cirrhotic cardiomyopathy (CCM), which is characterized by blunted myocardial contractile responsiveness to physical, physiological and pharmacological stress. Importantly, cardiac dysfunction can be reversible and can improve due to effective medical treatment and also after liver transplantation. Echocardiography and electrocardiography are essential tools for recognizing the characteristic changes in the myocardial function and also the alterations in the electrophysiological properties of the heart. Laboratory markers are auxiliary modalities further aiding the establishment of the correct diagnosis. In this review, we aimed to collect the pathophysiological background and clinical characteristics of CCM with the intention of summarizing the current possibilities for the diagnosis establishment and treatment of this cardio-hepatic disorder.

Original languageEnglish
Pages (from-to)301-310
Number of pages10
JournalJournal of Gastrointestinal and Liver Diseases
Volume23
Issue number3
DOIs
Publication statusPublished - 2014

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Keywords

  • Arrhythmias
  • Cardiomyopathy
  • Heart failure
  • Liver cirrhosis

ASJC Scopus subject areas

  • Gastroenterology

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