Pathomorphological characteristics and pathogenesis of viral hepatitis

Z. Schaff, G. Lotz, Rolf Schulte-Herman

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Viral hepatitis (VH) is an inflammatory reaction of the liver to hepatotropic viruses. Acute VH can be classified according to the virus and type of necrosis. Chronic hepatitis (CH) might be active, persistent or lobular based on previous classification. More recently the grade (necroinflammatory activity) and stage (fibrosis and architectural distorsion) of CH have been distinguished and scored. Apoptosis and necrosis probably coexist in VH and contribute to hepatocyte death. Several "death factors", such as transforming growth factor ß, Apol/Fas and tumor necrosis factor play a role in the execution of cell death. Injury of hepatocytes during viral infection can occur as a direct effect of the virus or as a result of the host immune response. Expression of different viral antigens can be detected during VH and might be visualized. Phenotyping of the portal inflammatory cell infiltrate in CH has shown a T-cell zone comprised of CD4+ helper T cells and CD8+ supressor/cytotoxic T cells at the periphery of the lobules. The pathogenetic mechanisms responsible for the final outcome of viral infection depend on viral factors (such as genotype, mutation etc.), virushost interaction, expression of viral protein, several cytokines etc. which finally lead to the well known histological alterations of viral hepatitis.

Original languageEnglish
Pages (from-to)132-143
Number of pages12
JournalPathology and Oncology Research
Volume2
Issue number3
DOIs
Publication statusPublished - Sep 1996

Fingerprint

Hepatitis
Chronic Hepatitis
Virus Diseases
Viruses
Hepatocytes
Necrosis
T-Lymphocytes
Viral Antigens
Transforming Growth Factors
Viral Proteins
Helper-Inducer T-Lymphocytes
Fibrosis
Cell Death
Tumor Necrosis Factor-alpha
Genotype
Apoptosis
Cytokines
Mutation
Liver
Wounds and Injuries

Keywords

  • hepatitis
  • pathogenesis
  • pathomorphology
  • viral

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

Cite this

Pathomorphological characteristics and pathogenesis of viral hepatitis. / Schaff, Z.; Lotz, G.; Schulte-Herman, Rolf.

In: Pathology and Oncology Research, Vol. 2, No. 3, 09.1996, p. 132-143.

Research output: Contribution to journalArticle

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