A csontvelofibrosis patomechanizmusa és elofordulása neoplasticus kórképekben

Translated title of the contribution: Pathomechanism and clinical impact of myelofibrosis in neoplastic diseases of the bone marrow

Judit Bedekovics, G. Méhes

Research output: Contribution to journalArticle

Abstract

Polyclonal mesenchymal cells (fibroblasts, endothelial cells, pericytes, osteoblasts, reticular cells, adipocytes, etc.) of the bone marrow create a functional microenvironment, which actively contributes to the maintenance of hemopoesis. This takes place through cellular interactions via growth factors, cytokines, adhesion molecules and extracellular matrix components, as well as through the control of calcium and oxygen concentration. Inflammatory and neoplastic diseases of the bone marrow result in pathologic interaction between hemopoietic progenitors and stromal cells. This may lead to the activation and expansion of the stroma and to the accumulation of reticulin and collagen fibers produced by mesenchymal cells. Clinically relevant fiber accumulation, termed as myelofibrosis accompanies many diseases, although, the extent and the consequence of myelofibrosis are variable in different disorders. The aim of this review is to summarize basic features of the normal bone marrow mesenchymal environment and the pathological process leading to myelofibrosis. In addition, the special features of myelofibrosis in bone marrow diseases, including myeloproliferative neoplasia, myelodysplastic syndrome and other neoplastic conditions are discussed.

Original languageHungarian
Pages (from-to)367-375
Number of pages9
JournalOrvosi Hetilap
Volume155
Issue number10
DOIs
Publication statusPublished - Mar 1 2014

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Bone Marrow Diseases
Primary Myelofibrosis
Bone Marrow
Reticulin
Pericytes
Myelodysplastic Syndromes
Pathologic Processes
Stromal Cells
Osteoblasts
Adipocytes
Extracellular Matrix
Intercellular Signaling Peptides and Proteins
Collagen
Stem Cells
Endothelial Cells
Fibroblasts
Maintenance
Cytokines
Oxygen
Calcium

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A csontvelofibrosis patomechanizmusa és elofordulása neoplasticus kórképekben. / Bedekovics, Judit; Méhes, G.

In: Orvosi Hetilap, Vol. 155, No. 10, 01.03.2014, p. 367-375.

Research output: Contribution to journalArticle

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