Pathological features of N-methyl-N'-nitro-N-nitrosoguanidine induced neoplastic and preneoplastic lesions of rat stomach.

J. Sugar, Z. Szentirmay, J. Kralovanszky

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Malignant transformation of rat stomach was studied after oral administration of MNNG. The lesions were investigated with cytomorphological and histochemical methods, while the alkaline phosphatase (ALP) isoenzyme pattern was investigated by means of gel electrophoresis. Hyperdiploid-aneuploid DNA values were observed in dysplasias, as well as in carcinomas. The liver type ALP isoenzyme could be detected in intact and regenerative gastric mucosa. It also occurred in atypical hyperplasia and carcinoma. Placental type ALP isoenzyme was absent in all intact or regenerating gastric mucosa, but present in atypical hyperplasias and carcinomas. It can be concluded that DNA aneuploidy and the presence of placental type ALP are indicative of malignant transformations. The MNNG-induced adenomatous hyperplasia associated with atypia behaved like cancer and can thus be regarded as an obligatory preneoplastic lesion.

Original languageEnglish
Pages (from-to)667-675
Number of pages9
JournalIARC scientific publications
Issue number31
Publication statusPublished - 1980

Fingerprint

Methylnitronitrosoguanidine
Hyperplasia
Stomach
Aneuploidy
Gastric Mucosa
Carcinoma
Isoenzymes
Alkaline Phosphatase
Polyploidy
DNA
Oral Administration
Electrophoresis
Gels
Liver
Neoplasms
placental alkaline phosphatase

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pathological features of N-methyl-N'-nitro-N-nitrosoguanidine induced neoplastic and preneoplastic lesions of rat stomach. / Sugar, J.; Szentirmay, Z.; Kralovanszky, J.

In: IARC scientific publications, No. 31, 1980, p. 667-675.

Research output: Contribution to journalArticle

@article{4a12739432be4df18fc953a3c8fa6208,
title = "Pathological features of N-methyl-N'-nitro-N-nitrosoguanidine induced neoplastic and preneoplastic lesions of rat stomach.",
abstract = "Malignant transformation of rat stomach was studied after oral administration of MNNG. The lesions were investigated with cytomorphological and histochemical methods, while the alkaline phosphatase (ALP) isoenzyme pattern was investigated by means of gel electrophoresis. Hyperdiploid-aneuploid DNA values were observed in dysplasias, as well as in carcinomas. The liver type ALP isoenzyme could be detected in intact and regenerative gastric mucosa. It also occurred in atypical hyperplasia and carcinoma. Placental type ALP isoenzyme was absent in all intact or regenerating gastric mucosa, but present in atypical hyperplasias and carcinomas. It can be concluded that DNA aneuploidy and the presence of placental type ALP are indicative of malignant transformations. The MNNG-induced adenomatous hyperplasia associated with atypia behaved like cancer and can thus be regarded as an obligatory preneoplastic lesion.",
author = "J. Sugar and Z. Szentirmay and J. Kralovanszky",
year = "1980",
language = "English",
pages = "667--675",
journal = "IARC (International Agency for Research on Cancer) Scientific Publications",
issn = "0300-5038",
publisher = "IARC",
number = "31",

}

TY - JOUR

T1 - Pathological features of N-methyl-N'-nitro-N-nitrosoguanidine induced neoplastic and preneoplastic lesions of rat stomach.

AU - Sugar, J.

AU - Szentirmay, Z.

AU - Kralovanszky, J.

PY - 1980

Y1 - 1980

N2 - Malignant transformation of rat stomach was studied after oral administration of MNNG. The lesions were investigated with cytomorphological and histochemical methods, while the alkaline phosphatase (ALP) isoenzyme pattern was investigated by means of gel electrophoresis. Hyperdiploid-aneuploid DNA values were observed in dysplasias, as well as in carcinomas. The liver type ALP isoenzyme could be detected in intact and regenerative gastric mucosa. It also occurred in atypical hyperplasia and carcinoma. Placental type ALP isoenzyme was absent in all intact or regenerating gastric mucosa, but present in atypical hyperplasias and carcinomas. It can be concluded that DNA aneuploidy and the presence of placental type ALP are indicative of malignant transformations. The MNNG-induced adenomatous hyperplasia associated with atypia behaved like cancer and can thus be regarded as an obligatory preneoplastic lesion.

AB - Malignant transformation of rat stomach was studied after oral administration of MNNG. The lesions were investigated with cytomorphological and histochemical methods, while the alkaline phosphatase (ALP) isoenzyme pattern was investigated by means of gel electrophoresis. Hyperdiploid-aneuploid DNA values were observed in dysplasias, as well as in carcinomas. The liver type ALP isoenzyme could be detected in intact and regenerative gastric mucosa. It also occurred in atypical hyperplasia and carcinoma. Placental type ALP isoenzyme was absent in all intact or regenerating gastric mucosa, but present in atypical hyperplasias and carcinomas. It can be concluded that DNA aneuploidy and the presence of placental type ALP are indicative of malignant transformations. The MNNG-induced adenomatous hyperplasia associated with atypia behaved like cancer and can thus be regarded as an obligatory preneoplastic lesion.

UR - http://www.scopus.com/inward/record.url?scp=0019249536&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019249536&partnerID=8YFLogxK

M3 - Article

SP - 667

EP - 675

JO - IARC (International Agency for Research on Cancer) Scientific Publications

JF - IARC (International Agency for Research on Cancer) Scientific Publications

SN - 0300-5038

IS - 31

ER -