Patológiai komplett remisszió preoperatív, nagy dózisteljesítményu{double acute} brachyterá piát követo{double acute}en operábilis mé hnyakdaganatos betegeknél: Egy prospektív, randomizált vizsgálat elo{double acute}zetes eredményei

Translated title of the contribution: Pathological complete remission after preoperative high-dose-rate brachytherapy in patients with operable cervical cancer: Preliminary results of a prospective randomized study

Júlia Vízkeleti, Imre Pete, Ildikó Vereczkey, Georgina Fröhlich, Katalin Horváth, Szilvia Varga, Tamás Pulay, Miklós Kásler, Csaba Polgár

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The purpose of the study was a preliminary evaluation of the efficacy of preoperative intracavitary high-dose-rate brachytherapy (HDR BT) in sterilization of the specimen of operable cervical cancer patients enrolled into a prospective, randomized study. Between 2005 and 2010, 100 operable cervical cancer patients of FIGO stage I/A2 (n=4), I/B1 (n=51), I/B2 (n=19), IIA (n=17), and proximal II/B (n=9) were randomized in two arms: in arm "A" (n=50) allocated treatment was 2×8 Gy preoperative intracavitary HDR BT followed by radical surgery, in arm "B" (n= 50) no preoperative treatment was given before the planned radical Wertheim hysterectomy. The rates of pathologic complete remission (pCR) were compared using the Fisher-exact test. In arm "A" 41 patients (82%), in arm "B" 42 patients (84%) underwent radical hysterectomy. The rate of pCR after preoperative BT was 26.8% (11/41), while in the control group the specimen was free of tumor in 7.1% (3/42; p=0.0204). Preoperative HDR BT for cervical cancer patients significantly increases the rate of pathologically tumor-free specimens. Longer follow-up is needed to evaluate the impact of pCR on local tumor control and survival. Our preliminary results support further enrollment of patients into our randomized clinical trial.

Translated title of the contributionPathological complete remission after preoperative high-dose-rate brachytherapy in patients with operable cervical cancer: Preliminary results of a prospective randomized study
Original languageHungarian
Pages (from-to)171-177
Number of pages7
JournalMagyar onkologia
Volume56
Issue number3
Publication statusPublished - 2012

ASJC Scopus subject areas

  • Medicine(all)

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