Pathological changes in cystic craniopharyngiomas following intracavital90yttrium treatment

G. T. Szeifert, J. Julow, F. Slowik, K. Bálint, F. Lányi, E. Pásztor

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Radiosurgery, using90Y injected directly into the cavity of cystic craniopharyngiomas produces remarkable reduction of tumour size and diminishes cyst fluid production. The authors have studied the histology of biopsy and autopsy material obtained from seven patients presented with cystic craniopharyngiomas. Histological examination was carried out before and after90Y silicate implantation. As an effect of90Y irradiation, histology of samples taken from the cyst wall revealed that the lining epithelial cell layer became destroyed and the cyst wall shrunk. Large amount of collagen fibres with focal hyaline degeneration was present. Proliferation of intimal cells and subendothelial connective tissue narrowing small vessel lumina also occurred. Considering that fibrotic tissue is more susceptible to shrink, the fibrosis induced by irradiation together with destruction of the squamous epithelium and vascular changes, might explain the reduction of the cyst volume and diminished fluid secretion after90Y treatment.

Original languageEnglish
Pages (from-to)14-18
Number of pages5
JournalActa Neurochirurgica
Volume102
Issue number1-2
DOIs
Publication statusPublished - Mar 1 1990

Keywords

  • Craniopharyngiomas
  • histological findings
  • intracavital irradiation
  • yttrium

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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