Pathological aspects of lipid peroxidation

Anne Negre-Salvayre, Nathalie Auge, Victoria Ayala, Huveyda Basaga, Jordi Boada, Rainer Brenke, Sarah Chapple, Guy Cohen, Janos Feher, Tilman Grune, Gabriella Lengyel, Giovanni E. Mann, Reinald Pamplona, Giuseppe Poli, Manuel Portero-Otin, Yael Riahi, Robert Salvayre, Shlomo Sasson, Jose Serrano, Ofer ShamniWerner Siems, Richard C.M. Siow, Ingrid Wiswedel, Kamelija Zarkovic, Neven Zarkovic

Research output: Contribution to journalReview article

261 Citations (Scopus)


Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular and cellular dysfunction that plays a major role in ageing and most age-related and oxidative stress-related diseases. The current evidence for the implication of LPO in pathological processes is discussed in this review. New data and literature review are provided evaluating the role of LPO in the pathophysiology of ageing and classically oxidative stress-linked diseases, such as neurodegenerative diseases, diabetes and atherosclerosis (the main cause of cardiovascular complications). Striking evidences implicating LPO in foetal vascular dysfunction occurring in pre-eclampsia, in renal and liver diseases, as well as their role as cause and consequence to cancer development are addressed.

Original languageEnglish
Pages (from-to)1125-1171
Number of pages47
JournalFree radical research
Issue number10
Publication statusPublished - Oct 1 2010


  • 4-Hydroxynonenal
  • 4-hydroxydodecadienal
  • 4-hydroxynonenal
  • Alzheimer ' s disease
  • HELLP syndrome
  • IUGR
  • Nrf2
  • Oxidative stress
  • Parkinson ' s disease
  • advanced glycation end-products
  • amyotrophic lateral sclerosis
  • antioxidant enzymes
  • atherosclerosis
  • cancer
  • cell signalling
  • diabetes
  • diabetes complications
  • fatty liver
  • foetal endothelium
  • glutathione
  • hyperglycaemia
  • lipid peroxidation
  • liver disease
  • lymphoedema
  • neurodegenerative diseases
  • oxidative homeostasis
  • oxidized phospholipids
  • oxysterol
  • pre-eclampsia
  • reactive oxygen species
  • redox equilibrium
  • redox signaling
  • renal diseases

ASJC Scopus subject areas

  • Biochemistry

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  • Cite this

    Negre-Salvayre, A., Auge, N., Ayala, V., Basaga, H., Boada, J., Brenke, R., Chapple, S., Cohen, G., Feher, J., Grune, T., Lengyel, G., Mann, G. E., Pamplona, R., Poli, G., Portero-Otin, M., Riahi, Y., Salvayre, R., Sasson, S., Serrano, J., ... Zarkovic, N. (2010). Pathological aspects of lipid peroxidation. Free radical research, 44(10), 1125-1171.