Pathologic Lesions Caused by Coinfection of Mycoplasma gallisepticum and H3N8 Low Pathogenic Avian Influenza Virus in Chickens

L. Stipkovits, R. Glavits, V. Pálfi, A. Beres, L. Egyed, B. Dénes, M. Somogyi, S. Szathmary

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Chickens were infected under experimental conditions with Mycoplasma gallisepticum and low pathogenic avian influenza (LPAI) strain A/mallard/Hungary/19616/07 (H3N8). Two groups of chickens were aerosol challenged with M. gallisepticum strain 1226. Seven days later, one of these groups and one mycoplasma-free group was challenged with LPAI H3N8 virus; one group without challenge remained as negative control. Eight days later, the birds were euthanized and examined for gross pathologic and histologic lesions. The body weight was measured, and the presence of antimycoplasma and antiviral antibodies was tested before the mycoplasma challenge, before the virus challenge, and at the end of the study to confirm both infections. Chickens in the mycoplasma-infected group developed antibodies against M. gallisepticum but not against the influenza virus. Chickens of the group infected with the influenza virus became serologically positive only against the virus, while the birds in the coinfected group developed antibodies against both agents. The LPAI H3N8 virus strain did not cause decrease in body weight and clinical signs, and macroscopic pathological lesions were not present in the chickens. The M. gallisepticum infection caused respiratory signs, airsacculitis, and peritonitis characteristic of mycoplasma infection. However, the clinical signs and pathologic lesions and the reduction in weight gain were much more significant in the group challenged with both M. gallisepticum and LPAI H3N8 virus than in the group challenged with M. gallisepticum alone.

Original languageEnglish
Pages (from-to)273-283
Number of pages11
JournalVeterinary Pathology
Volume49
Issue number2
DOIs
Publication statusPublished - Mar 2012

Fingerprint

Mycoplasma gallisepticum
Influenza in Birds
Orthomyxoviridae
Coinfection
mixed infection
Influenza A virus
lesions (animal)
H3N8 Subtype Influenza A Virus
Chickens
avian influenza
chickens
Mycoplasma
Mycoplasma Infections
antibodies
Birds
Antibodies
Body Weight
Viruses
mycoplasmosis
viruses

Keywords

  • bacterial
  • immunologic/inflammation
  • infectious
  • poultry
  • respiratory
  • viral

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Pathologic Lesions Caused by Coinfection of Mycoplasma gallisepticum and H3N8 Low Pathogenic Avian Influenza Virus in Chickens. / Stipkovits, L.; Glavits, R.; Pálfi, V.; Beres, A.; Egyed, L.; Dénes, B.; Somogyi, M.; Szathmary, S.

In: Veterinary Pathology, Vol. 49, No. 2, 03.2012, p. 273-283.

Research output: Contribution to journalArticle

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