A köpenysejtes lymphoma patológiai diagnózisa hisztológiai, citológiai, immunhisztológiai és genetikai jellemzók alapján.

Translated title of the contribution: Pathologic diagnosis of mantle cell lymphoma based on histologic, cytologic, immunohistologic and genetic characteristics

T. László, B. Csernus, L. Krenács, G. Kelényi, A. Matolcsy

Research output: Contribution to journalArticle

Abstract

Mantle cell lymphoma (MCL) is a clinocopathologic entity representing a broad histologic and cytologic spectrum from cystic to the blastic form. The histologic, cytologic heterogeneity of MCLs may lead to diagnostic confusion. The aim of this study was to reclassify NHLs registered as centrocytic lymphoma and centrocytoid-centroblastoma by the Lymphoma Reference Centrum at the Department of Pathology, University Medical School of Pécs between 1988 and 1995. 63 of 67 selected cases have been classified as mantle cell lymphoma according to histological, cytological appearance, and the pheno- and genotype of tumour cells. 48% of the cases showed diffuse while 52% showed nodular histological pattern. 27% of diffuse MCLs composed of classic MCL cells (small to medium-size cells) 40% blastic and 33% both small and blastic lymphoma cells. In 76% of the nodular MCLs the tumour consisted of small to medium-size cells 15% blastic while 9% both small and blastic lymphoma cells. In 99% of MCL the diagnosis was supported by CD5, CD20 and CD23 positivity and in 67% by the presence of cyclin D1-overexpression. The t(11;14) chromosome translocation PCR amplification was positive in 3 of 17 cases investigated. The authors conclude that MCLs represent a heterogeneous disease based on the cytology of the tumour cells. The nodular architecture was associated with classic MCL cells while the diffuse form was more frequently associated with blastic or combined cytological appearance. The correct diagnosis of MCL could be reached by tumour cell immunophenotyping, while molecular genetic methods proved to be informative only in part of the cases studied.

Original languageHungarian
Pages (from-to)2907-2912
Number of pages6
JournalOrvosi Hetilap
Volume140
Issue number52
Publication statusPublished - Dec 26 1999

Fingerprint

Mantle-Cell Lymphoma
B-Cell Chronic Lymphocytic Leukemia
Cell Size
Lymphoma
Neoplasms
Chromosomes, Human, Pair 14
Immunophenotyping
Chromosomes, Human, Pair 11
Cyclin D1
Medical Schools
Cell Biology
Molecular Biology
Genotype
Pathology
Phenotype
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A köpenysejtes lymphoma patológiai diagnózisa hisztológiai, citológiai, immunhisztológiai és genetikai jellemzók alapján. / László, T.; Csernus, B.; Krenács, L.; Kelényi, G.; Matolcsy, A.

In: Orvosi Hetilap, Vol. 140, No. 52, 26.12.1999, p. 2907-2912.

Research output: Contribution to journalArticle

@article{7c323b17efd54cb7a6ead0d3d15a7485,
title = "A k{\"o}penysejtes lymphoma patol{\'o}giai diagn{\'o}zisa hisztol{\'o}giai, citol{\'o}giai, immunhisztol{\'o}giai {\'e}s genetikai jellemz{\'o}k alapj{\'a}n.",
abstract = "Mantle cell lymphoma (MCL) is a clinocopathologic entity representing a broad histologic and cytologic spectrum from cystic to the blastic form. The histologic, cytologic heterogeneity of MCLs may lead to diagnostic confusion. The aim of this study was to reclassify NHLs registered as centrocytic lymphoma and centrocytoid-centroblastoma by the Lymphoma Reference Centrum at the Department of Pathology, University Medical School of P{\'e}cs between 1988 and 1995. 63 of 67 selected cases have been classified as mantle cell lymphoma according to histological, cytological appearance, and the pheno- and genotype of tumour cells. 48{\%} of the cases showed diffuse while 52{\%} showed nodular histological pattern. 27{\%} of diffuse MCLs composed of classic MCL cells (small to medium-size cells) 40{\%} blastic and 33{\%} both small and blastic lymphoma cells. In 76{\%} of the nodular MCLs the tumour consisted of small to medium-size cells 15{\%} blastic while 9{\%} both small and blastic lymphoma cells. In 99{\%} of MCL the diagnosis was supported by CD5, CD20 and CD23 positivity and in 67{\%} by the presence of cyclin D1-overexpression. The t(11;14) chromosome translocation PCR amplification was positive in 3 of 17 cases investigated. The authors conclude that MCLs represent a heterogeneous disease based on the cytology of the tumour cells. The nodular architecture was associated with classic MCL cells while the diffuse form was more frequently associated with blastic or combined cytological appearance. The correct diagnosis of MCL could be reached by tumour cell immunophenotyping, while molecular genetic methods proved to be informative only in part of the cases studied.",
author = "T. L{\'a}szl{\'o} and B. Csernus and L. Kren{\'a}cs and G. Kel{\'e}nyi and A. Matolcsy",
year = "1999",
month = "12",
day = "26",
language = "Hungarian",
volume = "140",
pages = "2907--2912",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "52",

}

TY - JOUR

T1 - A köpenysejtes lymphoma patológiai diagnózisa hisztológiai, citológiai, immunhisztológiai és genetikai jellemzók alapján.

AU - László, T.

AU - Csernus, B.

AU - Krenács, L.

AU - Kelényi, G.

AU - Matolcsy, A.

PY - 1999/12/26

Y1 - 1999/12/26

N2 - Mantle cell lymphoma (MCL) is a clinocopathologic entity representing a broad histologic and cytologic spectrum from cystic to the blastic form. The histologic, cytologic heterogeneity of MCLs may lead to diagnostic confusion. The aim of this study was to reclassify NHLs registered as centrocytic lymphoma and centrocytoid-centroblastoma by the Lymphoma Reference Centrum at the Department of Pathology, University Medical School of Pécs between 1988 and 1995. 63 of 67 selected cases have been classified as mantle cell lymphoma according to histological, cytological appearance, and the pheno- and genotype of tumour cells. 48% of the cases showed diffuse while 52% showed nodular histological pattern. 27% of diffuse MCLs composed of classic MCL cells (small to medium-size cells) 40% blastic and 33% both small and blastic lymphoma cells. In 76% of the nodular MCLs the tumour consisted of small to medium-size cells 15% blastic while 9% both small and blastic lymphoma cells. In 99% of MCL the diagnosis was supported by CD5, CD20 and CD23 positivity and in 67% by the presence of cyclin D1-overexpression. The t(11;14) chromosome translocation PCR amplification was positive in 3 of 17 cases investigated. The authors conclude that MCLs represent a heterogeneous disease based on the cytology of the tumour cells. The nodular architecture was associated with classic MCL cells while the diffuse form was more frequently associated with blastic or combined cytological appearance. The correct diagnosis of MCL could be reached by tumour cell immunophenotyping, while molecular genetic methods proved to be informative only in part of the cases studied.

AB - Mantle cell lymphoma (MCL) is a clinocopathologic entity representing a broad histologic and cytologic spectrum from cystic to the blastic form. The histologic, cytologic heterogeneity of MCLs may lead to diagnostic confusion. The aim of this study was to reclassify NHLs registered as centrocytic lymphoma and centrocytoid-centroblastoma by the Lymphoma Reference Centrum at the Department of Pathology, University Medical School of Pécs between 1988 and 1995. 63 of 67 selected cases have been classified as mantle cell lymphoma according to histological, cytological appearance, and the pheno- and genotype of tumour cells. 48% of the cases showed diffuse while 52% showed nodular histological pattern. 27% of diffuse MCLs composed of classic MCL cells (small to medium-size cells) 40% blastic and 33% both small and blastic lymphoma cells. In 76% of the nodular MCLs the tumour consisted of small to medium-size cells 15% blastic while 9% both small and blastic lymphoma cells. In 99% of MCL the diagnosis was supported by CD5, CD20 and CD23 positivity and in 67% by the presence of cyclin D1-overexpression. The t(11;14) chromosome translocation PCR amplification was positive in 3 of 17 cases investigated. The authors conclude that MCLs represent a heterogeneous disease based on the cytology of the tumour cells. The nodular architecture was associated with classic MCL cells while the diffuse form was more frequently associated with blastic or combined cytological appearance. The correct diagnosis of MCL could be reached by tumour cell immunophenotyping, while molecular genetic methods proved to be informative only in part of the cases studied.

UR - http://www.scopus.com/inward/record.url?scp=0033607862&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033607862&partnerID=8YFLogxK

M3 - Article

C2 - 10659642

AN - SCOPUS:0033607862

VL - 140

SP - 2907

EP - 2912

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

IS - 52

ER -