Pathogenic interactions between alcohol and hepatitis C

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

Alcohol is the most commonly abused substance in the United States, and alcohol abuse leads to alcoholic liver disease, a long recognized major public health concern. The high prevalence of chronic hepatitis C virus (HCV) infection, along with the clinical observation that HCV infection is common in alcoholic patients presenting with liver disease, has directed attention to the interaction between alcohol and HCV infection. Clinical studies have identified alcohol use as an independent risk factor for progression of fibrosis in chronic HCV infection. Experimental evidence suggests additive inhibitory effects between HCV and alcohol on antiviral immune responses. In addition, specific pathways have been identified by which HCV core protein and alcohol interact to activate hepatocytes. Nonspecific inflammatory cell recruitment and proinflammatory cytokine activation have also been implicated in both alcohol- and HCV-induced liver diseases. Further investigation of these and other pathways by which alcohol and HCV interact should unravel the mechanisms that accelerate the progression of liver disease.

Original languageEnglish
Pages (from-to)86-92
Number of pages7
JournalCurrent Gastroenterology Reports
Volume5
Issue number1
Publication statusPublished - Feb 2003

Fingerprint

Hepatitis C
Hepacivirus
Alcohols
Virus Diseases
Liver Diseases
Chronic Hepatitis C
Alcoholic Liver Diseases
Alcoholics
Alcoholism
Antiviral Agents
Hepatocytes
Fibrosis
Public Health
Cytokines

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pathogenic interactions between alcohol and hepatitis C. / Szabó, G.

In: Current Gastroenterology Reports, Vol. 5, No. 1, 02.2003, p. 86-92.

Research output: Contribution to journalReview article

@article{3d4e24b5f1ba4c4f85c401f3bf1851f9,
title = "Pathogenic interactions between alcohol and hepatitis C",
abstract = "Alcohol is the most commonly abused substance in the United States, and alcohol abuse leads to alcoholic liver disease, a long recognized major public health concern. The high prevalence of chronic hepatitis C virus (HCV) infection, along with the clinical observation that HCV infection is common in alcoholic patients presenting with liver disease, has directed attention to the interaction between alcohol and HCV infection. Clinical studies have identified alcohol use as an independent risk factor for progression of fibrosis in chronic HCV infection. Experimental evidence suggests additive inhibitory effects between HCV and alcohol on antiviral immune responses. In addition, specific pathways have been identified by which HCV core protein and alcohol interact to activate hepatocytes. Nonspecific inflammatory cell recruitment and proinflammatory cytokine activation have also been implicated in both alcohol- and HCV-induced liver diseases. Further investigation of these and other pathways by which alcohol and HCV interact should unravel the mechanisms that accelerate the progression of liver disease.",
author = "G. Szab{\'o}",
year = "2003",
month = "2",
language = "English",
volume = "5",
pages = "86--92",
journal = "Current Gastroenterology Reports",
issn = "1522-8037",
publisher = "Current Medicine Group",
number = "1",

}

TY - JOUR

T1 - Pathogenic interactions between alcohol and hepatitis C

AU - Szabó, G.

PY - 2003/2

Y1 - 2003/2

N2 - Alcohol is the most commonly abused substance in the United States, and alcohol abuse leads to alcoholic liver disease, a long recognized major public health concern. The high prevalence of chronic hepatitis C virus (HCV) infection, along with the clinical observation that HCV infection is common in alcoholic patients presenting with liver disease, has directed attention to the interaction between alcohol and HCV infection. Clinical studies have identified alcohol use as an independent risk factor for progression of fibrosis in chronic HCV infection. Experimental evidence suggests additive inhibitory effects between HCV and alcohol on antiviral immune responses. In addition, specific pathways have been identified by which HCV core protein and alcohol interact to activate hepatocytes. Nonspecific inflammatory cell recruitment and proinflammatory cytokine activation have also been implicated in both alcohol- and HCV-induced liver diseases. Further investigation of these and other pathways by which alcohol and HCV interact should unravel the mechanisms that accelerate the progression of liver disease.

AB - Alcohol is the most commonly abused substance in the United States, and alcohol abuse leads to alcoholic liver disease, a long recognized major public health concern. The high prevalence of chronic hepatitis C virus (HCV) infection, along with the clinical observation that HCV infection is common in alcoholic patients presenting with liver disease, has directed attention to the interaction between alcohol and HCV infection. Clinical studies have identified alcohol use as an independent risk factor for progression of fibrosis in chronic HCV infection. Experimental evidence suggests additive inhibitory effects between HCV and alcohol on antiviral immune responses. In addition, specific pathways have been identified by which HCV core protein and alcohol interact to activate hepatocytes. Nonspecific inflammatory cell recruitment and proinflammatory cytokine activation have also been implicated in both alcohol- and HCV-induced liver diseases. Further investigation of these and other pathways by which alcohol and HCV interact should unravel the mechanisms that accelerate the progression of liver disease.

UR - http://www.scopus.com/inward/record.url?scp=0038621880&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038621880&partnerID=8YFLogxK

M3 - Review article

C2 - 12530953

AN - SCOPUS:0038621880

VL - 5

SP - 86

EP - 92

JO - Current Gastroenterology Reports

JF - Current Gastroenterology Reports

SN - 1522-8037

IS - 1

ER -