Pathogenic fungi regulate immunity by inducing neutrophilic myeloid-derived suppressor cells

Nikolaus Rieber, Anurag Singh, Hasan Öz, Melanie Carevic, Maria Bouzani, Jorge Amich, Michael Ost, Zhiyong Ye, Marlene Ballbach, Iris Schäfer, Markus Mezger, Sascha N. Klimosch, Alexander N R Weber, Rupert Handgretinger, Sven Krappmann, Johannes Liese, Maik Engeholm, Rebecca Schüle, Helmut Rainer Salih, L. Máródi & 7 others Carsten Speckmann, Bodo Grimbacher, Jürgen Ruland, Gordon D. Brown, Andreas Beilhack, Juergen Loeffler, Dominik Hartl

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Despite continuous contact with fungi, immunocompetent individuals rarely develop pro-inflammatory antifungal immune responses. The underlying tolerogenic mechanisms are incompletely understood. Using both mouse models and human patients, we show that infection with the human pathogenic fungi Aspergillus fumigatus and Candida albicans induces a distinct subset of neutrophilic myeloid-derived suppressor cells (MDSCs), which functionally suppress T and NK cell responses. Mechanistically, pathogenic fungi induce neutrophilic MDSCs through the pattern recognition receptor Dectin-1 and its downstream adaptor protein CARD9. Fungal MDSC induction is further dependent on pathways downstream of Dectin-1 signaling, notably reactive oxygen species (ROS) generation as well as caspase-8 activity and interleukin-1 (IL-1) production. Additionally, exogenous IL-1β induces MDSCs to comparable levels observed during C. albicans infection. Adoptive transfer and survival experiments show that MDSCs are protective during invasive C. albicans infection, but not A. fumigatus infection. These studies define an innate immune mechanism by which pathogenic fungi regulate host defense.

Original languageEnglish
Pages (from-to)507-514
Number of pages8
JournalCell Host and Microbe
Volume17
Issue number4
DOIs
Publication statusPublished - Apr 8 2015

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Immunity
Fungi
Candida albicans
Aspergillus fumigatus
Infection
Interleukin-1
Pattern Recognition Receptors
Adoptive Transfer
Caspase 8
Natural Killer Cells
Reactive Oxygen Species
Myeloid-Derived Suppressor Cells
T-Lymphocytes
Survival
Proteins
dectin 1

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Cancer Research
  • Molecular Biology

Cite this

Rieber, N., Singh, A., Öz, H., Carevic, M., Bouzani, M., Amich, J., ... Hartl, D. (2015). Pathogenic fungi regulate immunity by inducing neutrophilic myeloid-derived suppressor cells. Cell Host and Microbe, 17(4), 507-514. https://doi.org/10.1016/j.chom.2015.02.007

Pathogenic fungi regulate immunity by inducing neutrophilic myeloid-derived suppressor cells. / Rieber, Nikolaus; Singh, Anurag; Öz, Hasan; Carevic, Melanie; Bouzani, Maria; Amich, Jorge; Ost, Michael; Ye, Zhiyong; Ballbach, Marlene; Schäfer, Iris; Mezger, Markus; Klimosch, Sascha N.; Weber, Alexander N R; Handgretinger, Rupert; Krappmann, Sven; Liese, Johannes; Engeholm, Maik; Schüle, Rebecca; Salih, Helmut Rainer; Máródi, L.; Speckmann, Carsten; Grimbacher, Bodo; Ruland, Jürgen; Brown, Gordon D.; Beilhack, Andreas; Loeffler, Juergen; Hartl, Dominik.

In: Cell Host and Microbe, Vol. 17, No. 4, 08.04.2015, p. 507-514.

Research output: Contribution to journalArticle

Rieber, N, Singh, A, Öz, H, Carevic, M, Bouzani, M, Amich, J, Ost, M, Ye, Z, Ballbach, M, Schäfer, I, Mezger, M, Klimosch, SN, Weber, ANR, Handgretinger, R, Krappmann, S, Liese, J, Engeholm, M, Schüle, R, Salih, HR, Máródi, L, Speckmann, C, Grimbacher, B, Ruland, J, Brown, GD, Beilhack, A, Loeffler, J & Hartl, D 2015, 'Pathogenic fungi regulate immunity by inducing neutrophilic myeloid-derived suppressor cells', Cell Host and Microbe, vol. 17, no. 4, pp. 507-514. https://doi.org/10.1016/j.chom.2015.02.007
Rieber, Nikolaus ; Singh, Anurag ; Öz, Hasan ; Carevic, Melanie ; Bouzani, Maria ; Amich, Jorge ; Ost, Michael ; Ye, Zhiyong ; Ballbach, Marlene ; Schäfer, Iris ; Mezger, Markus ; Klimosch, Sascha N. ; Weber, Alexander N R ; Handgretinger, Rupert ; Krappmann, Sven ; Liese, Johannes ; Engeholm, Maik ; Schüle, Rebecca ; Salih, Helmut Rainer ; Máródi, L. ; Speckmann, Carsten ; Grimbacher, Bodo ; Ruland, Jürgen ; Brown, Gordon D. ; Beilhack, Andreas ; Loeffler, Juergen ; Hartl, Dominik. / Pathogenic fungi regulate immunity by inducing neutrophilic myeloid-derived suppressor cells. In: Cell Host and Microbe. 2015 ; Vol. 17, No. 4. pp. 507-514.
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