A mikro-RNS-ek patogenetikai és diagnosztikai szerepe mellékvesekéreg-carcinomában

Translated title of the contribution: Pathogenic and diagnostic roles of microRNAs in adrenocortical tumours

Nagy Zoltán, Decmann Abel, Perge Pál, P. Igaz

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Adrenocortical tumours are quite prevalent. Most of these tumours are benign, hormonally inactive adrenocortical adenomas. Rare hormone-secreting adrenocortical adenomas are associated with severe clinical consequences, whereas the prognosis of the rare adrenocortical cancer is rather poor in its advanced stages. The pathogenesis of these tumours is only partly elucidated. MicroRNAs are small, non-coding RNA molecules that are pivotal in the regulation of several basic cell biological processes via the posttranscriptional regulation of gene expression. Their altered expression has been described in many tumours. Several tissue microRNAs, such as miR-483-5p, miR-503, miR-210, miR-335 and miR-195 were found to be differentially expressed among benign and malignant adrenocortical tumours, and these could also have pathogenic relevance. Due to their tissue specific and stable expression, microRNAs can be exploited in diagnostics as well. As the histological diagnosis of adrenocortical malignancy is difficult, microRNAs might be of help in the establishment of malignancy. Novel data show that microRNAs are secreted in various body fluids, projecting their applicability as biomarkers as part of liquid biopsy. In this review, we attempt to present a synopsis on the pathogenic relevance of microRNAs in adrenocortical tumours and their potential diagnostic applicability.

Original languageHungarian
Pages (from-to)245-251
Number of pages7
JournalOrvosi Hetilap
Volume159
Issue number7
DOIs
Publication statusPublished - Feb 1 2018

Fingerprint

MicroRNAs
Neoplasms
Adrenocortical Adenoma
Adrenal Cortex Neoplasms
Biological Phenomena
Small Untranslated RNA
Gene Expression Regulation
Body Fluids
Biomarkers
Hormones
Biopsy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A mikro-RNS-ek patogenetikai és diagnosztikai szerepe mellékvesekéreg-carcinomában. / Zoltán, Nagy; Abel, Decmann; Pál, Perge; Igaz, P.

In: Orvosi Hetilap, Vol. 159, No. 7, 01.02.2018, p. 245-251.

Research output: Contribution to journalArticle

Zoltán, Nagy ; Abel, Decmann ; Pál, Perge ; Igaz, P. / A mikro-RNS-ek patogenetikai és diagnosztikai szerepe mellékvesekéreg-carcinomában. In: Orvosi Hetilap. 2018 ; Vol. 159, No. 7. pp. 245-251.
@article{1061b5170107459b8e8b2b293f6c64dc,
title = "A mikro-RNS-ek patogenetikai {\'e}s diagnosztikai szerepe mell{\'e}kvesek{\'e}reg-carcinom{\'a}ban",
abstract = "Adrenocortical tumours are quite prevalent. Most of these tumours are benign, hormonally inactive adrenocortical adenomas. Rare hormone-secreting adrenocortical adenomas are associated with severe clinical consequences, whereas the prognosis of the rare adrenocortical cancer is rather poor in its advanced stages. The pathogenesis of these tumours is only partly elucidated. MicroRNAs are small, non-coding RNA molecules that are pivotal in the regulation of several basic cell biological processes via the posttranscriptional regulation of gene expression. Their altered expression has been described in many tumours. Several tissue microRNAs, such as miR-483-5p, miR-503, miR-210, miR-335 and miR-195 were found to be differentially expressed among benign and malignant adrenocortical tumours, and these could also have pathogenic relevance. Due to their tissue specific and stable expression, microRNAs can be exploited in diagnostics as well. As the histological diagnosis of adrenocortical malignancy is difficult, microRNAs might be of help in the establishment of malignancy. Novel data show that microRNAs are secreted in various body fluids, projecting their applicability as biomarkers as part of liquid biopsy. In this review, we attempt to present a synopsis on the pathogenic relevance of microRNAs in adrenocortical tumours and their potential diagnostic applicability.",
keywords = "Adrenocortical cancer, Circulating, Extracellular vesicle, MicroRNA, Tissue",
author = "Nagy Zolt{\'a}n and Decmann Abel and Perge P{\'a}l and P. Igaz",
year = "2018",
month = "2",
day = "1",
doi = "10.1556/650.2018.30919",
language = "Hungarian",
volume = "159",
pages = "245--251",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "7",

}

TY - JOUR

T1 - A mikro-RNS-ek patogenetikai és diagnosztikai szerepe mellékvesekéreg-carcinomában

AU - Zoltán, Nagy

AU - Abel, Decmann

AU - Pál, Perge

AU - Igaz, P.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Adrenocortical tumours are quite prevalent. Most of these tumours are benign, hormonally inactive adrenocortical adenomas. Rare hormone-secreting adrenocortical adenomas are associated with severe clinical consequences, whereas the prognosis of the rare adrenocortical cancer is rather poor in its advanced stages. The pathogenesis of these tumours is only partly elucidated. MicroRNAs are small, non-coding RNA molecules that are pivotal in the regulation of several basic cell biological processes via the posttranscriptional regulation of gene expression. Their altered expression has been described in many tumours. Several tissue microRNAs, such as miR-483-5p, miR-503, miR-210, miR-335 and miR-195 were found to be differentially expressed among benign and malignant adrenocortical tumours, and these could also have pathogenic relevance. Due to their tissue specific and stable expression, microRNAs can be exploited in diagnostics as well. As the histological diagnosis of adrenocortical malignancy is difficult, microRNAs might be of help in the establishment of malignancy. Novel data show that microRNAs are secreted in various body fluids, projecting their applicability as biomarkers as part of liquid biopsy. In this review, we attempt to present a synopsis on the pathogenic relevance of microRNAs in adrenocortical tumours and their potential diagnostic applicability.

AB - Adrenocortical tumours are quite prevalent. Most of these tumours are benign, hormonally inactive adrenocortical adenomas. Rare hormone-secreting adrenocortical adenomas are associated with severe clinical consequences, whereas the prognosis of the rare adrenocortical cancer is rather poor in its advanced stages. The pathogenesis of these tumours is only partly elucidated. MicroRNAs are small, non-coding RNA molecules that are pivotal in the regulation of several basic cell biological processes via the posttranscriptional regulation of gene expression. Their altered expression has been described in many tumours. Several tissue microRNAs, such as miR-483-5p, miR-503, miR-210, miR-335 and miR-195 were found to be differentially expressed among benign and malignant adrenocortical tumours, and these could also have pathogenic relevance. Due to their tissue specific and stable expression, microRNAs can be exploited in diagnostics as well. As the histological diagnosis of adrenocortical malignancy is difficult, microRNAs might be of help in the establishment of malignancy. Novel data show that microRNAs are secreted in various body fluids, projecting their applicability as biomarkers as part of liquid biopsy. In this review, we attempt to present a synopsis on the pathogenic relevance of microRNAs in adrenocortical tumours and their potential diagnostic applicability.

KW - Adrenocortical cancer

KW - Circulating

KW - Extracellular vesicle

KW - MicroRNA

KW - Tissue

UR - http://www.scopus.com/inward/record.url?scp=85041943466&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041943466&partnerID=8YFLogxK

U2 - 10.1556/650.2018.30919

DO - 10.1556/650.2018.30919

M3 - Article

VL - 159

SP - 245

EP - 251

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

IS - 7

ER -